Results 71 to 80 of about 15,400 (157)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Preserving balance in the EU digital single market: How Like Company could reframe copyright and innovation in the generative AI era

The Journal of World Intellectual Property, EarlyView.
Abstract This article analyses the Court of Justice of the European Union's first referral on generative AI and copyright, i.e., Case C‐250/25 Like Company v. Google, which interrogates whether the generation of chatbot summaries of press articles infringes the press publishers' right under Article 15 CDSM Directive and the reproduction and ...
Enrico Bonadio, Giancarlo Frosio, Christophe Geiger, Andres Guadamuz, Stavroula Karapapa, Irini Stamatoudi   +5 more
wiley   +1 more source

Factor V Leiden and Prothrombin Mutations in South of Iran

Armaghane Danesh Bimonthly Journal, 2007
: Introduction & Objective: Factor V Leiden and prothrombin mutation are not common but they are involved in pediatric thrombosis. The aim of this study was to evaluate the frequency of factor V Leiden & prohtrombin mutation in healthy population of ...
M Karimi, AR Panahande, AR Afrasiabi
doaj  

An AGC kinase cascade regulates ROP signaling for the correct timing of pollen germination

New Phytologist, EarlyView.
Model for PDK1‐AGC1.5/7 kinase cascade function in controlling pollen germination. Summary In flowering plants, the timing of pollen germination is crucial for successful fertilization and an important trait for seed and fruit crops. Environmental factors tightly regulate pollen germination, with germination‐suppressing conditions on the pollen ...
Tong Zhao, Andrea Lepper, Franziska Anzenberger, Sarah Brajkovic, Kim König, Hiromasa Shikata, Yao Xiao, Bernhard Küster, Claus Schwechheimer, Remko Offringa, Philipp Denninger   +10 more
wiley   +1 more source

A single‐nucleus multiome profiling reveals the regulatory programs driving plant nematode–induced syncytium

New Phytologist, EarlyView.
Single‐nucleus transcriptome profiles of Heterodera schachtii–induced syncytium on Arabidopsis roots. Summary Plant‐parasitic cyst nematodes induce the formation of specialized feeding structures, known as syncytia, within host roots by orchestrating extensive transcriptional and epigenetic reprogramming.
Tarek Hewezi, Sobhan Bahrami Zadegan, Peitong Li, Cengizhan Öztürk, J. Hollis Rice, Hari B. Krishnan   +5 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory‐Based Analysis

Journal of Magnetic Resonance Imaging, Volume 64, Issue 5, Page 1241-1249, November 2026.
ABSTRACT Background Cerebral microbleeds (CMBs) are a key imaging marker of cerebral amyloid angiopathy (CAA), but their individual spatial distribution and potential clustering remain poorly understood. Purpose This study assessed whether CMBs exhibit patient‐specific, flow territory‐based clustering in sporadic (sCAA) and Dutch‐type hereditary CAA (D‐
Manon R. Schipper, Reinier G. J. van der Zwet, Jelle J. Goeman, Thijs W. van Harten, Emma A. Koemans, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Matthias J. P. van Osch   +7 more
wiley   +1 more source

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

Cancer Science, Volume 117, Issue 11, Page 2938-2952, November 2026.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia, Fengming Xu, Tao Zhou, Pingping Wang, Huiping Chen, Jing Zhang, Xiaochen Yuan, Haoxun Xu, Yu Ouyang   +8 more
wiley   +1 more source

Factor V Leiden Mutation in Women with Recurrent Pregnancy Loss: A Single-center Study

Acta Haematologica Oncologica Turcica
Aim: Recurrent pregnancy loss (RPL) affects approximately 1-2% of women of reproductive age and remains a clinically challenging condition with diverse underlying causes.
Aslı Odabaşı Giden, Çağrı Doğan
doaj   +1 more source

A YAP–TEAD–CTCF Transcriptional Regulatory Axis Associated With the Elimination of Injured Hepatocytes From the Liver

Genes to Cells, Volume 31, Issue 6, November 2026.
Injured YAP‐activated hepatocytes are eliminated from the liver. They are extruded toward the sinusoidal lumen, undergo cell death, and are phagocytosed by macrophages. Here, we performed proximity ligation assay, ATAC‐seq, RNA‐seq, and CellChat analyses.
Daiki Hatakeyama, Yoshimi Okamoto‐Uchida, Misaki Kosaka, Haruka Hirose, Satoshi Kofuji, Keiko Danzaki, Yoshiki Endo, Michiko Nakagawa, Akinori Kanai, Yutaka Suzuki, Takeshi Yokoo, Shuji Terai, Teppei Shimamura, Hiroshi Nishina   +13 more
wiley   +1 more source