Results 101 to 110 of about 12,736,036 (293)

THE EFFICACY OF RECOMBINANT ACTIVATED FACTOR VII (COAGIL VII) FOR TREATMENT HAEMORRHAGE AND HAEMOSTASIS DISORDES DURING THORACIC AORTA OPERATIONS

Вестник анестезиологии и реаниматологии, 2019
Goal: to evaluate the efficacy and safety of domestic (home-produced) recombinant factor VIIa (Coagil VII) for massive bleeding and haemostasis disordes treatment in thoracic aorta surgery. Methods.
N. A. TREKOVA, D. A. GUSKOV, A. V. GONCHAROVA, B. A. AKSELROD   +3 more
doaj   +1 more source

Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells [PDF]

, 1999
We provide evidence from a newly established, conditionally immortal cell line (UB/UE-1) that vestibular supporting cells from the mammalian inner ear can differentiate postnatally into more than one variant of hair cell.
Holley, M.C., Kros, C.J., Lawlor, P., Marcotti, W., Rivolta, M.N.   +4 more
core   +1 more source

Pattern of Detections Across Multiple Environmental Messenger RNAs (e‐mRNAs) in Stressor‐Exposed Zebrafish (Danio rerio)

Ecology and Evolution, Volume 16, Issue 1, January 2026.
We evaluated e‐mRNAs of known molecular targets of perfluorooctanesulfonic acid (PFOS) toxicity in zebrafish in a controlled laboratory experiment. The detection patterns of e‐mRNAs in our study imply that diminishing detection of these traces over time is a strong indicator of target organism presence (or very recent presence), providing a narrower ...
Denise L. Lindsay, J. Erik Mylroie, Kurt A. Gust, Elijah M. Cowan, Richard F. Lance   +4 more
wiley   +1 more source

Acquired Hemophilia A Presenting as Intramuscular Hematoma

Journal of Investigative Medicine High Impact Case Reports, 2018
Acquired hemophilia A poses a clinical and diagnostic challenge. Although rare, it is still the most common acquired factor deficiency. We present a case of acquired hemophilia A diagnosed in a 71-year-old female who presented with a right thigh hematoma
Ghassan Al-Shbool MD, Anusha Vakiti MD
doaj   +1 more source

Entering new areas in known fields: recombinant fusion protein linking recombinant factor VIIa with recombinant albumin (rVIIa-FP) – advancing the journey [PDF]

, 2016
The novel fusion protein linking recombinant factor VIIa with recombinant albumin (rVIIa-FP) is designed to extend the half-life of recombinant factor VIIa (rFVIIa) and improve the care of hemophilia A or B patients with inhibitors.
Legrand, Michel R, Preunkert, Suzanne, Weller, Rolf   +2 more
core   +1 more source

Altered Inflammatory Signature in a C9ORF72 ‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, Volume 74, Issue 1, January 2026.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Emicizumab in Previously Untreated Patients and Minimally Treated Patients With Hemophilia A: A Comparative Study Between Two International Cohorts

Pediatric Blood &Cancer, Volume 73, Issue 1, January 2026.
ABSTRACT Background Hemophilia A (HA) is a rare bleeding disorder caused by coagulation factor VIII (FVIII) deficiency. Prophylactic FVIII replacement therapy is essential for preventing bleeds, but it carries a risk of inhibitor development, especially in previously untreated and minimally treated patients (PUPs and MTPs, respectively).
Sarina Levy‐Mendelovich, Tlalit Barhod, Ivan Budnik, Jonathan Lancashire, Jesal Patel, Assaf Arie Barg, Einat Avishai, Rima Dardik, Tami Brutman Barazani, Tami Livnat, Jayashree Motwani, Gili Kenet   +11 more
wiley   +1 more source

Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients

Drug Design, Development and Therapy, 2010
John PuetzSaint Louis University, Department of Pediatrics, St Louis, Missouri, USAAbstract: One of the last remaining clinical hurdles in the treatment of people with hemophilia is the development of inhibitors. Alloantibodies or autoantibodies directed
John Puetz
doaj  

Study of the A(e,e'$\pi^+$) Reaction on $^1$H, $^2$H, $^{12}$C, $^{27}$Al, $^{63}$Cu and $^{197}$Au

, 2009
Cross sections for the p($e,e'\pi^{+}$)n process on $^1$H, $^2$H, $^{12}$C, $^{27}$Al, $^{63}$Cu and $^{197}$Au targets were measured at the Thomas Jefferson National Accelerator Facility (Jefferson Lab) in order to extract the nuclear transparencies ...
A. Aste, A. Bruell, A. Daniel, A. F. Lung, A. H. Mueller, A. K. Opper, A. Matsumura, A. Villano, A. W. Rauf, B. Clasie, C. E. Keppel, C. Gray, C. Perdrisat, D. Day, D. Dutta, D. G. Meekins, D. Gaskell, D. Rohe, E. Chudakov, E. Segbefia, F. Benmokhtar, F. R. Wesselmann, G. M. Huber, G. Niculescu, G. R. Smith, H. C. Fenker, H. Gao, H. Mkrtchyan, I. Niculescu, J. Arrington, J. Ferrer, J. Seely, K. Garrow, K. Kramer, L. El Fassi, L. Tang, L. Yuan, M. E. Christy, M. K. Jones, M. M. Dalton, M. Sumihama, N. Fomin, N. Kalantarians, P. Bosted, P. Markowitz, R. Asaturyan, R. Ent, R. J. Glauber, R. Monson, S. A. Wood, S. J. Brodsky, S. Malace, T. Horn, T. Mertens, T. Miyoshi, T. Navasardyan, V. M. Rodriquez, V. Punjabi, V. Tadevosyan, W. Boeglin, W. F. Vulcan, X. Qian, X. Zheng, Y. Li, Y. Liang, Y. Okayasu   +65 more
core   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, Volume 22, Issue 1, 2 January 2026.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source