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Recombinant Factor VIIa

BioDrugs, 1999
Recombinant factor VIIa is a preparation of activated coagulation factor VII (factor VIIa) that is produced by recombinant DNA technology. The drug expedites blood coagulation without the need for factors VIII and IX in patients with haemophilia. Indicators of activation of systemic coagulation of blood were unchanged and mean prothrombin times and ...
C J, Dunn, C M, Spencer
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Synthetic substrates for human factor VIIa and factor VIIa-tissue factor

Biochemistry, 1993
A series of 100 tripeptide fluorogenic substrates has been synthesized. These substrates contain Arg in the P1 position, various amino acids in the P2 and P3 positions, and different 6-amino-1-naphthalenesulfonamides (ANSN) as the detecting group (P').
S, Butenas, N, Ribarik, K G, Mann
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Tissue Factor-dependent Factor VIIa Signaling

Trends in Cardiovascular Medicine, 2000
Tissue factor (TF) is known primary as a cofactor for factor VIIa-mediated triggering of blood coagulation, which proceeds in a cascade of extracellular reactions. Recent investigations have, however, revealed that intracellular activities can also be induced by the proteolytic activity of factor VIIa bound to cell surface TF.
L C, Petersen, P, Freskgård, M, Ezban
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