BRD9 inhibition as potential treatment option for testicular germ cell tumors
Andrology, EarlyView.Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen +5 more
wiley +1 more source
In Silico Design of Novel Anticoagulant Peptides targeting Blood Coagulation Factor VIIa
Sultan Qaboos University Medical Journal, 2011 Objectives: The coagulation cascade initiated during vascular injury prevents bleeding. Unwanted clot formation is however detrimental and requires the use of anticoagulants for prophylaxis and treatment.
Manal S Q Al-Amri +3 more
doaj
The use of recombinant factor VIIa in a pediatric septic shock patient with disseminated intravascular coagulation [PDF]
Einstein (São Paulo), 2008 This is a report on a pediatric patient with septic shock and disseminated intravascular coagulation, who developed life-threatening bleeding which was successfully treated with recombinant factor VIIa.
Ronaldo Arkader +2 more
doaj
Trombastenia de Glanzmann. Histerectomia vaginal de urgência tratada com factor VIIa recombinante.
Acta Médica Portuguesa, 2004 In the present article, regarding a clinical case of Thrombasthenia of Glanzmann with severe anaemia by menometrorrhagia, the authors propose the vaginal hysterectomy and the administration of the recombinant factor VIIa on the immediate pre and ...
João S Mairos +10 more
doaj +1 more source
Diffuse alveolar hemorrhage and recombinant factor VIIa treatment in pediatric patients [PDF]
Korean Journal of Pediatrics, 2016 Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders.
Jeong A Park
doaj +1 more source
Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
British Journal of Pharmacology, EarlyView.Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam +12 more
wiley +1 more source
Mediterranean Journal of Hematology and Infectious Diseases, 2014 Diffuse alveolar hemorrhage is a serious complication post stem cell transplantation with no proven definitive treatment, resulting in high mortality. Recombinant factor VIIa has been occassionaly used in such patients with good results. We report here a
Dharma Choudhary +3 more
doaj
Stroke intensive care: voice a view
Анналы клинической и экспериментальной неврологии, 2007 Modern methods of acute stroke treatment are analyzed: traditional and mechanical thrombolysis, intraventricular thrombolysis, recombinant activated factor VIIa for acute intracerebral hemorrhage, hemicraniectomy.
M. A. Piradov
doaj +1 more source
Activated recombinant factor VIIa should not be used in patients with refractory variceal bleeding: it is mostly ineffective, is expensive, and may rarely cause serious adverse events [PDF]
, 2014 Activated Recombinant Factor VIIa Does Not Improve Mortality in Variceal Bleeding. Bendtsen F, D’Amico G, Rusch E, de Franchis R, Anderson PK, Lebrec D, et al. Effect of recombinant Factor VIIa on outcome of acute variceal bleeding: An individual patient
Chalasani, Naga, Sozio, Margaret S.
core +1 more source
Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells
The FEBS Journal, EarlyView.Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari +6 more
wiley +1 more source