Results 61 to 70 of about 4,918,610 (234)

Anode Materials Requirements for Potassium Ion Batteries: Challenges and Future Possibilities

EcoEnergy, EarlyView.
This work identifies a critical scale‐up gap between laboratory battery research and industrial targets, driven by low active‐mass loadings and the omission of full‐cell metrics. We outline concrete strategies to bridge this divide, shifting focus toward high‐loading electrodes (> 3 mg cm−2) to ensure practical commercial viability of potassium ion ...
Md. Robiul Alam, Sahithi Thatipamula, Muhammad Waqas Khan, Suraj Loomba, Sharafadeen Gbadamasi, Muhammad Haris, Xian Jian, Asif Mahmood, Mahdokht Shaibani, Nasir Mahmood   +9 more
wiley   +1 more source

Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling.

, 1998
The signaling pathway initiated by factor Xa on vascular endothelial cells was investigated. Factor Xa stimulated a 5- to 10-fold increased release of nitric oxide (NO) in a dose-dependent reaction (0.1-2.5 μg/ml) unaffected by the thrombin inhibitor ...
CICALA, CARLA, JOHNSON K, BUCCI, MARIAROSARIA, PAPAPETROPOULOS A, SORRENTINO R, SESSA W, ALTIERI D., CIRINO, GIUSEPPE, ZACHARIOU V, PICCARDONI P, Giuseppe Cirino, Raffaella Sorrentino, Andreas Papapetropoulos, Carla Cicala, Kirk Johnson, Paola Piccardoni, Mariarosaria Bucci, Dario C. Altieri, Venetia Zachariou, William C. Sessa   +19 more
core   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source

Activated prothrombin complex concentrate to reverse the factor Xa inhibitor (apixaban) effect before emergency surgery: a case series

Journal of Medical Case Reports, 2018
Background The lack of an antidote against factor Xa inhibitors in case of major bleeding or need for urgent surgery is a concern to clinicians. Guidelines on managing major bleeding in patients under anticoagulation with a factor Xa inhibitor suggest ...
Nina Haagenrud Schultz, Runar Lundblad, Pål Andre Holme   +2 more
doaj   +1 more source

Exploring Elimination Profiles and Metabolite Patterns of Brinzolamide and Dorzolamide After Transdermal Exposure for Doping Control Purposes

ELECTROPHORESIS, EarlyView.
Dermal exposure to the carbonic anhydrase inhibitors dorzolamide and brinzolamide is detected in blood and urine using liquid chromatography–high‐resolution/high‐accuracy mass spectrometry. Contamination at milligram level can, therefore, lead to adverse analytical findings in sports drug testing.
Yao Jin, Andreas Thomas, Mario Thevis
wiley   +1 more source

Use of natural ensiling additives with tropical grasses: Physicochemical properties, in vitro fermentation characteristics, and microbial community diversity indices

JSFA reports, EarlyView.
Abstract Background Improving feed quality, availability, and cost‐effectiveness is a big challenge for livestock to ensure animal‐derived food for nutritional security. The aim of the study was to find out how some natural ensiling additives affect physicochemical properties, proximate composition, microbial population, in vitro fermentation ...
A. B. M. Rubayet Bostami, A. S. M. Selim, M. Al‐Mamun, K. M. Islam, M. D. Hossain   +4 more
wiley   +1 more source

Predictors of hematoma expansion in intracerebral hemorrhage associated with factor Xa inhibitors

Frontiers in Neurology
BackgroundImproving the outcomes of patients with intracerebral hemorrhage (ICH) associated with factor Xa inhibitors remains a clinical challenge. Andexanet alfa, a specific reversal agent for factor Xa inhibitors, has the potential to mitigate hematoma
Yoji Komatsu, Takao Koiso, Tomokazu Sekine, Kazuki Akutagawa, Kazuki Akutagawa, Hiroki Karita, Hiroki Karita, Norie Kikuchi, Tomosato Yamazaki, Tomosato Yamazaki   +9 more
doaj   +1 more source

The Supporting Scaffold as a Structural Module for Plant Cystatin Design

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein engineering approaches have been proposed to improve the inhibitory potency of cystatins against plant pest digestive Cys proteases, typically involving point mutations in the N‐terminal trunk or inhibitory loops known to interact with the target protease.
Jonathan Tremblay, Kristina LeBreux, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +4 more
wiley   +1 more source

Possible Factor Xa Resistance in a Patient Who Failed Apixaban and Rivaroxaban

Clinical Case Reports
This article aims to discuss the literature on switching to an anticoagulant with a different mechanism of action in case of treatment failure. We present a patient with atrial fibrillation who incurred an embolic stroke despite adequate anticoagulation ...
Ola Ali, Awab Elnaeem, Manmeet Kaur, Nitisha Thatikonda, Julia Aigbogun, A. K. M. Muktadir   +5 more
doaj   +1 more source

PREDICTORS OF THE RISK OF HEMORRHAGIC EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION RECEIVING LONGTERM THERAPY WITH DIRECT ORAL ANTICOAGULANTS

Рациональная фармакотерапия в кардиологии, 2017
Aim. To study the initial disorders in the coagulation system, as factors influencing the development of bleeding during anticoagulant therapy with direct oral anticoagulants (DOAC).Material and methods.
A. А. Sokolova, A. V. Zhilenko, I. L. Tsarev,, D. A. Napalkov, V. V. Fomin   +4 more
doaj   +1 more source