Results 81 to 90 of about 4,918,610 (234)

Peri‐operative management of patients having day surgery: a consensus statement from the Association of Anaesthetists, British Association for Day Surgery and the Association of Paediatric Anaesthetists, Great Britain and Ireland

Anaesthesia, EarlyView.
Summary Introduction Day surgery is now recognised widely as being a vital component of modern healthcare delivery with overall day surgery rates in the UK now > 85%. Day surgery offers an enhanced experience for patients with reduced risk of postoperative complications (e.g.
Craig R. Bailey, David Bunting, Lindsay Hudman, Shivan Kanani, Kirstin May, Catalina Stendall, Rachel Tibble, Allan Xu, Matthew D. Wiles   +8 more
wiley   +1 more source

Crystallization Control and Physicochemical Properties of Polymorphic Forms of the Factor Xa Inhibitor KFA-1982

, 2016
Many polymorphs of KFA-1982, an orally active factor Xa (fXa) inhibitor, have been identified and their physicochemical properties have been investigated.
Harunobu Mukaiyama (2091427), Hideki Takeuchi (574016), Eiichi Tsuji (2091415), Yuichiro Kai (2091421), Kenji Yokoyama (2091430), Katsuhide Terada (2016769), Koji Kamata (2091424), Kazumichi Jo (2091418)   +7 more
core   +1 more source

Pulmonary Embolism—A Century of Progress

ANZ Journal of Surgery, EarlyView.
Reviews a century of progress in the diagnosis, prevention, and management of pulmonary embolism; from the first successful surgical embolectomy in 1924 to advanced imaging, pharmacological thromboprophylaxis, and treatment. In the 21st century, advances include catheter‐directed thrombolysis or mechanical thrombectomy under decision‐making guidance of
D. A. Watters
wiley   +1 more source

Factor Xa as an interface between coagulation and inflammation. Molecular mimicry of factor Xa association with effector cell protease receptor-1 induces acute inflammation in vivo.

, 1997
Coagulation proteases were tested in a rat model of acute inflammation. Subplantar injection of Factor Xa (10-30 microg) produced a time- and dose-dependent edema in the rat paw, and potentiated carrageenin-induced edema.
G. Ambrosini, CIRINO, GIUSEPPE, G. DeDominicis, CICALA, CARLA, M Bucci, G Ambrosini, D. C. Altieri, D C Altieri, C Cicala, L Sorrentino, G DeDominicis, BUCCI, MARIAROSARIA, L. Sorrentino, G Cirino   +13 more
core   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review

Haemophilia, EarlyView.
ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson, Roy Khalife, Kelsey Uminski   +2 more
wiley   +1 more source

Thromboelastography may assess the effect of anticoagulation reversal in intracranial hemorrhage

Journal of Stroke and Cerebrovascular Diseases
Background: Intracranial hemorrhage (ICH) is a complication of oral anticoagulation and is associated with significant morbidity and mortality. Clinical need exists for biomarkers to measure anticoagulation in patients with factor Xa inhibitor-associated
A Zepeski, BA Faine, M Ghannam, HM Olalde, L Wendt, A Naidech, NM Mohr, EC Leira   +7 more
doaj   +1 more source

Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate

, 2018
The relative clinical efficacy of 4-factor prothrombin complex concentrate (4F-PCC) in oral anticoagulant-associated intracranial hemorrhage is unknown, especially for factor Xa-inhibiting anticoagulants.
John S. Garrett, Sarah K. Harrison, Jeffrey A. Kline, Kline, Jeffrey A., Kohman, Kelsey N., Harrison, Sarah K., Kelsey N. Kohman, Garrett, John S.   +7 more
core   +1 more source

Activation of factor X and its regulation by tissue factor pathway inhibitor in small-diameter capillaries lined with human endothelial cells [PDF]

, 1992
The activation of factor X at the surface of endothelial cells was investigated under controlled flow conditions. A method is described for preparing polyethylene capillaries whose inner walls are covered with a confluent layer of human umbilical vein ...
Nordfang, Ole, Hemker, H. Coenraad, Lindhout, Theo, Reutelingsperger, Christiaan, Schoen, Pieter, Blezer, Ron   +5 more
core   +1 more source

Do We Really Know How to Manage Anticoagulated Patients for Periodontal Nonsurgical Therapy? An Observational Cohort Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives The aim of this work is to assess and compare the impact of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) during and immediately after periodontal nonsurgical therapy. Materials and Methods A prospective observational cohort study was conducted with patients who presented a history of cardiovascular disease ...
F. Berton, A. Rapani, F. Costantinides, V. Nicolin, D. Cuhureanu, R. Di Lenarda   +5 more
wiley   +1 more source