Results 91 to 100 of about 4,918,610 (234)

Case report: Severe hepatopathy following rivaroxaban administration in a dog

Frontiers in Veterinary Science
Rivaroxaban, a specific factor Xa inhibitor and commonly utilized anticoagulant, has been known to cause hepatotoxicity and liver failure in humans. Although rivaroxaban is frequently used in veterinary medicine, hepatotoxicity has not been previously ...
Allison P. Mosichuk, Candace Wimbish, Kristen Poplawski, Adam Birkenheuer, Karyn Harrell, Kursten V. Pierce   +5 more
doaj   +1 more source

Reversing factor Xa inhibitors – clinical utility of andexanet alfa

, 2017
Scott Kaatz,1 Hardik Bhansali,1 Joseph Gibbs,2 Robert Lavender,3 Charles E Mahan,4 David G Paje5 1Division of Hospital Medicine, 2Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 3Division of General Internal Medicine, University of ...
Gibbs J, Kaatz S, Bhansali H, Lavender R, Mahan CE, Paje DG   +5 more
core  

The Role of Catalytic Cleft and Exosite Residues of Factor VIIa for Complex Formation with Tissue Factor Pathway Inhibitor

, 2001
SummaryThe extrinsic coagulation pathway is initiated by the binding of plasma factor VIIa (VIIa) to the cell surface receptor tissue factor (TF). Formation of the TF-VIIa complex results in allosteric activation of VIIa as well as the creation of an ...
Alexei Iakhiaev, Wolfram Ruf, Vijaya Mohan Rao   +2 more
core   +1 more source

The DOAC‐FRAIL Study—Same Dose, Different Story: Prevalence of Deviant Direct Oral Anticoagulant Levels in Nursing Home Residents

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are prescribed using fixed dosing regimens, despite limited evidence on their pharmacokinetic behavior in nursing home residents. Participants and Setting One hundred nursing home residents are receiving apixaban, rivaroxaban, dabigatran, or edoxaban in multiple long‐term care facilities in the ...
Irme S. Franssen, Melanie J. de Jong, Lars Visseren, Daan Teerds, Dave Hellenbrand, Yvonne Henskens, Henri Spronk, Daisy J. A. Janssen, Dionne C. W. Braeken, Sander M. J. van Kuijk, Kristien Winckers, Fabienne J. H. Magdelijns   +11 more
wiley   +1 more source

Plasma ADAMTS13 activity in healthy dogs and dogs with chronic enteropathy

Journal of Small Animal Practice, EarlyView.
Objectives A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 is a von Willebrand factor cleaving enzyme that is associated with prothrombotic/hypercoagulable states in humans. In people, A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity is reduced with inflammatory bowel disease ...
S. I. Barth, S. M. DeMonaco, B. J. Conner, P. B. S. Serpa, A. R. Wilkinson   +4 more
wiley   +1 more source

Reversal of Factor Xa Inhibitors by Andexanet Alfa May Increase Thrombogenesis Compared to Pretreatment Values

Clinical and Applied Thrombosis/Hemostasis, 2019
Recombinant coagulation factor Xa (FXa), inactivated Zh-zo, also known as andexanet alfa (AA), is a modified version of human FXa that has been developed to neutralize FXa inhibitors.
Fakiha Siddiqui BDS, Alfonso Tafur MD, Lorenzo Storino Ramacciotti BS, Walter Jeske PhD, Debra Hoppensteadt PhD, Eduardo Ramacciotti MD, PhD, Omer Iqbal MD, FACC, FESC, Jawed Fareed PhD   +7 more
doaj   +1 more source

Role of platelet factor Xa in chylomicron-prothrombin complexes induced platelet activation

, 1995
The effects of chylomicron-prothrombin complexes on platelet activation, including platelet aggregation, serotonin release, arachidonic acid release and increases of platelet cytosolic [Ca2+]i were examined.
Öhlin, Ann-Kristin, Zhou, Li, Xu, Ning, Nilsson, Åke, Öhlin, Ann-Kristin,, Nilsson, Åke,, Zhou, Li,, Lund University., Xu, Ning,   +8 more
core   +1 more source

Retrospective evaluation of outcomes in dogs with non‐associative immune‐mediated haemolytic anaemia treated with rivaroxaban as a sole or adjunctive thromboprophylaxis agent: 34 cases (2018‐2024)

Journal of Small Animal Practice, EarlyView.
Objectives To describe clinical outcomes, thromboembolic and haemorrhagic complications, and treatment characteristics in dogs with non‐associative immune‐mediated haemolytic anaemia treated with rivaroxaban at a UK referral hospital. Materials and Methods Retrospective descriptive study of dogs diagnosed with non‐associative immune‐mediated haemolytic
S. Conway, L. Jenkins, J. Reeve
wiley   +1 more source

How Awareness of Orthographic Transparency Benefits the Lexical Encoding of Second Language Vowels

Language Learning, EarlyView.
Abstract We investigated the influence of orthographic transparency, and learners’ awareness of it, on the second language (L2) phonolexical encoding of Brazilian Portuguese (BP) mid‐vowel contrasts. In BP, accent marks indicate vowel quality (mid‐closed vs.
Hunter Brakovec, Isabelle Darcy
wiley   +1 more source

ERA OF NEW ANTICOAGULANTS IN THE TREATMENT OF NON-VALVULAR ATRIAL FIBRILLATION: PROSPECTS AND CHALLENGES

Рациональная фармакотерапия в кардиологии, 2015
Studies data on new anticoagulants, direct oral thrombin inhibitor (dabigatran) and direct inhibitors of coagulation factor Xa (rivaroxaban, apixaban), in the treatment of nonvalvular atrial fibrillation are presented.
Z. M. Safiullina, S. V. Shalaev
doaj   +1 more source