Cabbage seed protease inhibitor: a slow, tight-binding inhibitor of trypsin with activity toward thrombin, activated Stuart factor (factor Xa), activated Hageman factor (factor XIIa), and plasmin [PDF]
, 1990 Thomas H. Carter, BA Everson, Ratnoff Od
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Sainsc: A Computational Tool for Segmentation‐Free Analysis of In Situ Capture Data
Small Methods, EarlyView.Spatially resolved transcriptomics methods can now profile the entire transcriptome, at full organism scale with nanometre resolution. Analysis frameworks that can efficiently and intuitively process the massive data generated by these methods are lacking.
Niklas Müller‐Bötticher +3 more
wiley +1 more source
Exploring potential anticoagulant drug formulations using thrombin generation test
Biochemistry and Biophysics Reports, 2016 Many anticoagulant drugs inhibiting proteins of the coagulation cascade have been developed. The main targets of anticoagulant drugs are thrombin and factor Xa; inhibiting these factors delays thrombus growth, thus preventing thrombosis while increasing ...
Elena Zavyalova, Alexey Kopylov
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Ancylostoma caninum Anticoagulant Peptide: A novel inhibitor of coagulation factor Xa with potent antimetastatic activity. • 650 [PDF]
, 1997 Kathleen M. Donnelly +3 more
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Therapeutic Apheresis and Dialysis, EarlyView.Abstract Introduction This study aims to investigate patient factors affecting the rate of plasma volume target attained in hypertriglyceridemic pancreatitis (HTG‐AP) patients undergoing double filtration plasmapheresis (DFPP). Methods A retrospective analysis of 82 HTG‐AP‐interpreted patients from January 2019 to April 2024 compared target plasma ...
Hui Zhang, Chenqiang Zhu, Yunlong Wu
wiley +1 more source
Artificial Organs, EarlyView.Frailty significantly impacts clinical outcomes in LVAD recipients. This systematic review and meta‐analysis reveal that frail patients experience higher long‐term mortality but comparable short‐term mortality, hospital stay, and complication rates to non‐frail patients.
Christos Costa +15 more
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Modes of binding synthetic inhibitors to factor Xa: an automated docking approach [PDF]
, 1996 Mohan Rao, Arthur J. Olson
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British Journal of Clinical Pharmacology, EarlyView.Abstract Aim The aim of this study was to investigate the impact of pharmacist‐led person‐centred medicines reviews in general practices on medicines appropriateness, polypharmacy indicators (high‐risk prescribing markers), and patient‐reported outcome measures (PROMs).
Clare Kinahan +9 more
wiley +1 more source
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat [PDF]
Journal of Pharmacology and Experimental Therapeutics 323(2):
488-498 (2007), 2007 Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor necrosis factor-a (TNF-a) is involved in BBB injury and edema formation through a mechanism involving matrix metalloproteinase (MMP) upregulation. There is emerging evidence
arxiv
Management of heparin-induced thrombocytopenia with factor xa inhibitors: A systematic review
Thrombosis UpdateHeparin-induced thrombocytopenia (HIT) is a rare but severe prothrombotic disorder that develops in patients exposed to heparin products. Diagnosis is associated with significant morbidity and mortality.
Colton Jones +7 more
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