Results 201 to 210 of about 15,476,282 (336)

ClinGen Bayesian-Framework-Guided Interpretation of Compound Heterozygous <i>F12</i> Variants in a Pregnant Woman with Factor XII Deficiency: A Case Report. [PDF]

Diagnostics (Basel)
Park KS, Cho HE.
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Transient acquired factor XII deficiency associated with moderately severe Covid-19 pneumonia. [PDF]

Hematol Transfus Cell Ther, 2021
Murray NP, Guzman E, Del Prado M.
europepmc   +1 more source

Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation.

Blood, 2017
Ivan Ivanov, A. Matafonov, A. Matafonov, Mao-fu Sun, Qiufang Cheng, S. Dickeson, I. Verhamme, J. Emsley, D. Gailani   +8 more
semanticscholar   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Crystal structure of coagulation factor XII N-terminal domains 1-5. [PDF]

Acta Crystallogr D Struct Biol
Saleem M, Li C, Kaira BG, Brown AK, Pathak M, Najmudin S, Cowieson N, Dreveny I, Wilson C, Shamanaev A, Gailani D, Smith SA, Morrissey JH, Philippou H, Emsley J.   +14 more
europepmc   +1 more source

Pharmacokinetic/pharmacodynamic modeling for dose selection for the first-in-human trial of the activated Factor XII inhibitor garadacimab (CSL312). [PDF]

Clin Transl Sci, 2022
Pawaskar D, Chen X, Glassman F, May F, Roberts A, Biondo M, McKenzie A, Nolte MW, Jusko WJ, Tortorici M.   +9 more
europepmc   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Author Correction: Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. [PDF]

Nat Commun
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B.   +26 more
europepmc   +1 more source

Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study. [PDF]

World J Clin Cases, 2022
Meng Y, Li Y, Ye YJ, Ma Q, Zhang JB, Qin H, Deng YY, Tian HY.   +7 more
europepmc   +1 more source