Results 281 to 290 of about 15,476,282 (336)

Factor XII in coagulation, inflammation and beyond

Cellular Signalling, 2018
Factor XII (FXII) is a protease that is mainly produced in the liver and circulates in plasma as a single chain zymogen. Following contact with negatively charged surfaces, FXII is converted into the two-chain active form, FXIIa. FXIIa initiates the intrinsic blood coagulation pathway via activation of factor XI.
Miroslava, Didiasova, Lukasz, Wujak, Liliana, Schaefer, Malgorzata, Wygrecka   +3 more
openaire   +3 more sources

Factor XII(a) inhibitors: a review of the patent literature

Expert Opinion on Therapeutic Patents, 2021
Introduction: Blood coagulation factor XII (FXII) is an emerging and potentially safe drug target, which dysregulation is associated with thrombosis, hereditary angioedema, and (neuro)inflammation.
D. Kalinin
semanticscholar   +1 more source

Prevalence and Clinical Impact of Reduced Coagulation Factor XII Activity in Patients Receiving Extracorporeal Membrane Oxygenation

Critical Care Medicine, 2021
Supplemental Digital Content is available in the text. OBJECTIVES: Extracorporeal membrane oxygenation provides large surface exposure to human blood leading to coagulation activation.
Nina Buchtele, M. Schwameis, P. Schellongowski, P. Quehenberger, P. Knöbl, Ludwig Traby, M. Schmid, C. Schoergenhofer, H. Herkner, B. Jilma, T. Staudinger   +10 more
semanticscholar   +1 more source

Observation of Factor XII and Factor XII Deficient Plasma at an Interface

Thrombosis and Haemostasis, 1965
SummaryEllipsometry recordings and measurements, using wettable anodized tantalum slides (TaW), showed that an adsorbed film of factor XII deficient plasma could be partially removed by adding factor XII to the liquid medium.When factor XII was first adsorbed onto the slide, addition of factor XII deficient plasma caused adsorption followed by partial ...
A L, ADAMS, L, VROMAN
openaire   +2 more sources

Moderate Factor XII Deficiency

Thrombosis and Haemostasis, 1965
SummaryA case of “moderate” factor XII deficiency, with 3.6% factor XII activity, is reported. Because the activity of factor XII found in the parents of the patient is consistent with heterozygousity, the defect may be considered hereditary.
J, BOK, J J, VELTKAMP, E A, LOELIGER
openaire   +2 more sources

Molecular analysis of factor XII gene in Thai patients with factor XII deficiency

Blood Coagulation & Fibrinolysis, 2013
Factor XII is the initiating protein of the intrinsic coagulation pathway. It activates factor X after being activated by the so called 'contact system'. Both congenital factor XII deficiency, usually without bleeding symptoms, and several factor XII polymorphisms with possible thrombotic tendency have been described.
Pon, Singhamatr, Somjai, Kanjanapongkul, Ponlapat, Rojnuckarin   +2 more
openaire   +2 more sources

Autoactivatability of human Hageman factor (factor XII)

Biochemical and Biophysical Research Communications, 1980
Abstract Purified Hageman factor was found to autodigest upon binding to a negatively charged surface such as kaolin. Assessment by incorporation of tritiated diisopropylfluorophosphate indicated that this cleavage was accompanied by activation and that the two known forms of activated Hageman factor result.
G, Miller, M, Silverberg, A P, Kaplan
openaire   +2 more sources

Adsorption of hageman factor (factor XII) on collagen

Experientia, 1964
Nous avons trouve que le facteur Hageman (factor XII), contenu dans le plasma humain citrate, pauvre en plaquettes, est adsorbe presque selectivement par le collagene. Il est egalement possible d'eluer ce facteur au pH alcalin.
S, Niewiarowski, E, Bańkowski, T, Fiedoruk   +2 more
openaire   +2 more sources

The Relation of ‘Fletcher Factor’ to Factors XI and XII

British Journal of Haematology, 1970
Summary. Further evidence is presented for the existence of a new coagulation factor which is closely related to Hageman factor (XII) and plasma thromboplastin antecedent, PTA (XI). This factor has been tentatively designated ‘Fletcher factor’. Coagulant activity of Fletcher factor was separated from the clotting activity of factors XI and XII by C‐M ...
W E, Hathaway, J, Alsever
openaire   +2 more sources

Activation Of Factor XII By Dextran Sulfate: A Convenient Assay For Factor XII

Thrombosis and Haemostasis, 1981
The rapid reciprocal activation of Factor XII and prekallikrein by negatively charged surfaces requires the presence of high Mr kininogen. Our studies have demonstrated that high Mr kininogen is not required for the activation of Factor XII by the soluble activator, dextran sulfate (Mr 500,000).
D L Tankersley, B M Alving, J S Finlayson   +2 more
openaire   +1 more source