Results 41 to 50 of about 146,062 (286)

A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse. [PDF]

, 2012
Intragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation, and speciation.
Affara, Nabeel A., Burgoyne, Paul S., Cocquet, Julie, Ellis, Peter J.I., Mahadevaiah, Shantha K., Vaiman, Daniel   +5 more
core   +10 more sources

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells [PDF]

, 2018
RATIONALE: The majority of current cardiovascular cell therapy trials use bone marrow progenitor cells (BM PCs) and achieve only modest efficacy; the limited potential of these cells to differentiate into endothelial-lineage cells is one of the major ...
Boriboun, Chan, Chandel, Navdeep S., Cheng, Min, Dong, Nian-Guo, Harris, Robert A., Huang, Kai, Liu, Qinghua, Losordo, Douglas W., Qin, Gangjian, Qiu, Hongyu, Shi, Jiawei, Sun, Tianjiao, Tao, Jun, Xu, Shiyue, Yang, Liu, Zhang, Eric, Zhao, Ting C., Zhou, Junlan   +17 more
core   +1 more source

A Rare Cause of Isolated Prolonged Activated Partial Thromboplastin Time: An Overview of Prekallikrein Deficiency and the Contact System

Journal of Investigative Medicine High Impact Case Reports, 2021
Prekallikrein (PK) deficiency, also known as Fletcher factor deficiency, is a very rare disorder inherited as an autosomal recessive trait. It is usually identified incidentally in asymptomatic patients with a prolonged activated partial thromboplastin ...
Ivy Riano MD, Klaorat Prasongdee MD
doaj   +1 more source

The Coronae of AR Lac [PDF]

, 2003
We observed the coronally active eclipsing binary, AR Lac, with the High Energy Transmission Grating on Chandra for a total of 97 ks, spaced over five orbits, at quadratures and conjunctions.
Bowyer S., Brickhouse N. S., Claude R. Canizares, Craig I. J. D., David P. Huenemoerder, Frasca A., Gabriel A. H., Gehren T., Haisch B., Jeremy J. Drake, Jorge Sanz‐Forcada, Kaastra J. S., Kuerster M., Maggio A., Marino G., McIntosh S. W., Mewe R., Neff J. E., Ottmann R., Perryman M. A. C., Raymond J. C., Rodono M., White N. E.   +22 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Successful carotid endarterectomy in a patient with factor XII deficiency (Hageman disease): a case report

Zaporožskij Medicinskij Žurnal
Aim. To present the first documented case of successful carotid endarterectomy in a patient with severe Factor XII deficiency and analyze the features of perioperative management. Materials and methods.
M. O. Slabyi, H. Yu. Orel, O. M. Slabyi
doaj   +1 more source

Query-to-Communication Lifting for BPP

, 2017
For any $n$-bit boolean function $f$, we show that the randomized communication complexity of the composed function $f\circ g^n$, where $g$ is an index gadget, is characterized by the randomized decision tree complexity of $f$.
Göös, Mika, Pitassi, Toniann, Watson, Thomas   +2 more
core   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Late presentation of factor XIII deficiency with recurrent muscle hematomas

Indian Pediatrics Case Reports, 2023
Background: Plasma factor XIII is a proenzyme that gets activated in the final step of the coagulation cascade. Its physiological role is to stabilize clot formation by catalyzing the cross-linkage of fibrin.
Sudesh Kumar, Piyali Bhattacharya, Anamika Kumari   +2 more
doaj   +1 more source