Results 131 to 140 of about 14,368 (309)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Factorization of Hausdorff Operators

Axioms
Throughout this study, we will gain a deeper understanding of Hausdorff operators that are commonly used in operator theory. The Hausdorff matrices Gamma, Cesàro, and Hölder are factorized here to derive novel inequalities.
Hadi Roopaei
doaj   +1 more source

On the geometric interpretation of the nonnegative rank [PDF]

The nonnegative rank of a nonnegative matrix is the minimum number of nonnegative rank-one factors needed to reconstruct it exactly. The problem of determining this rank and computing the corresponding nonnegative factors is difficult; however it has ...
GILLIS, Nicolas, GLINEUR, François
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

On classical orthogonal polynomials and the Cholesky factorization of a class of Hankel matrices

Bulletin of Mathematical Sciences
Classical moment functionals (Hermite, Laguerre, Jacobi, Bessel) can be characterized as those linear functionals whose moments satisfy a second-order linear recurrence relation.
Misael E. Marriaga, Guillermo Vera de Salas, Marta Latorre, Rubén Muñoz Alcázar   +3 more
doaj   +1 more source

Factorization of Quasiseparable Matrices

, 2008
This paper investigates some of the ideas and algorithms developed for exploiting the structure of quasiseparable matrices. The case of purely scalar generators is considered initially. The process by which a quasiseparable matrix is represented as the
Johnson, Paul D.
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Visualization of and Software for Omnibus Test-Based Change Detected in a Time Series of Polarimetric SAR Data

Canadian Journal of Remote Sensing, 2017
Based on an omnibus likelihood ratio test statistic for the equality of several variance-covariance matrices following the complex Wishart distribution and a factorization of this test statistic with associated p-values, change analysis in a time series ...
Allan A. Nielsen, Knut Conradsen, Henning Skriver, Morton J. Canty   +3 more
doaj   +1 more source

Factoring Permutation Matrices Into a Product of Tridiagonal Matrices

, 2010
11 pages, 1 ...
Samson, Michael Daniel, Ezerman, Martianus Frederic   +1 more
openaire   +2 more sources

Computing Generalized Inverse Systems using Matrix Pencil Methods

, 2001
We address the numerically reliable computation of generalized inverses of rational matrices in descriptor state-space representation. We put particular emphasis on two classes of inverses: the weak generalized inverse and the Moore-Penrose pseudoinverse.
Varga, A., Varga, Andras
core