Results 71 to 80 of about 9,658 (265)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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ArrayTraditional wet experiments to identify drug–target interactions (DTIs) are costly and time consuming. Therefore, machine learning-based methods are commonly used to speed up the identification process.
Junjun Zhang, Tingfeng Zeng
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A finite-difference method for linearization in nonlinear estimation algorithms [PDF]
Modeling, Identification and Control, 1998 Linearizations of nonlinear functions that are based on Jacobian matrices often cannot be applied in practical applications of nonlinear estimation techniques. An alternative linearization method is presented in this paper.
Tor S. Schei
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Fast Computation for Square Matrix Factorization
ComputersIn this work, we discuss a method for the QR-factorization of N×N matrices where N≥3 which is based on transformations which are called discrete signal-induced heap transformations (DsiHTs). These transformations are generated by given signals and can be
Artyom M. Grigoryan
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
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Minor Prime Factorization for n-D Polynomial Matrices over Arbitrary Coefficient Field
Complexity, 2018 In this paper, we investigate two classes of multivariate (n-D) polynomial matrices whose coefficient field is arbitrary and the greatest common divisor of maximal order minors satisfy certain condition.
Jinwang Liu, Dongmei Li, Licui Zheng
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Factorization of generalized γ-generating matrices [PDF]
Journal of Mathematical Sciences, 2018 The class of \(\gamma\)-generating matrices and its subclasses of regular and singular \(\gamma\)-generating matrices were introduced in [\textit{D. Z. Arov}, J. Sov. Math. 52, No. 6, 3487--3491 (1990; Zbl 0718.41004); translation from Teor. Funkts., Funkts. Anal. Prilozh.
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source