Results 71 to 80 of about 115,750 (273)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Holomorphic Factorization of Matrices of Polynomials [PDF]

, 1999
This paper considers some work done by the author and Catlin [CD1,CD2,CD3] concerning positivity conditions for bihomogeneous polynomials and metrics on bundles over certain complex manifolds. It presents a simpler proof of a special case of the main result in [CD3], providing also a self-contained proof of a generalization of the main result from [CD1]
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Bidiagonal Factorizations of Filbert and Lilbert Matrices

Axioms
Extensions of Filbert and Lilbert matrices are addressed in this work. They are reciprocal Hankel matrices based on Fibonacci and Lucas numbers, respectively, and both are related to Hilbert matrices.
Yasmina Khiar, Esmeralda Mainar, Juan Manuel Peña, Eduardo Royo-Amondarain, Beatriz Rubio   +4 more
doaj   +1 more source

Evaluation of Partial Factorization for Reduction of Finite Element Matrices

Engineering Transactions, 2017
In this paper, we present the concept of Partial Factorization [1] And discuss its possible applications to the Finite Element method. We consider: (1) reduction of the element tangent matrix, which is particularly important for mixed/enhanced elements ...
Pawel JARZĘBSKI, Krzysztof WIŚNIEWSKI
doaj   +1 more source

On the matrix of rank one over a UFD [PDF]

Journal of Hyperstructures, 2016
In this paper we characterize all matrices of rank one over a unique factorization domain (UFD). Also we find the Rmodule generated by the rows and the R-module generated by the columns of a matrix of rank one and assert some properties of them.
Somayeh Hadjirezaei, Somayeh Karimzadeh
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Factorization identities and algebraic Bethe ansatz for D 2 2 $$ {D}_2^{(2)} $$ models

Journal of High Energy Physics, 2021
We express D 2 2 $$ {D}_2^{(2)} $$ transfer matrices as products of A 1 1 $$ {A}_1^{(1)} $$ transfer matrices, for both closed and open spin chains. We use these relations, which we call factorization identities, to solve the models by algebraic Bethe ...
Rafael I. Nepomechie, Ana L. Retore
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source