Results 91 to 100 of about 115,750 (273)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On matrices associated to prime factorization of odd integers
Condensed Matter Physics, 2008 In this paper we introduce in section 5 integral matrices M(n) for any factorization of an odd integer n into r distinct odd primes. The matrices appear in several versions according to a parameter ρ∈[0,1], they have size 2r×2r and their rank satisfies e.
T. Bier
doaj +1 more source
OCMA: Fast, Memory-Efficient Factorization of Prohibitively Large Relationship Matrices
G3: Genes, Genomes, Genetics, 2019 Matrices representing genetic relatedness among individuals (i.e., Genomic Relationship Matrices, GRMs) play a central role in genetic analysis. The eigen-decomposition of GRMs (or its alternative that generates fewer top singular values using genotype ...
Zhi Xiong +6 more
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On vector configurations that can be realized in the cone of positive matrices
, 2010 Let $v_1$,..., $v_n$ be $n$ vectors in an inner product space. Can we find a natural number $d$ and positive (semidefinite) complex matrices $A_1$,..., $A_n$ of size $d \times d$ such that ${\rm Tr}(A_kA_l)= $ for all $k,l=1,..., n$? For such matrices to
Frenkel, Péter E., Weiner, Mihály
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Effective Temporal Graph Learning via Personalized PageRank
EntropyGraph representation learning aims to map nodes or edges within a graph using low-dimensional vectors, while preserving as much topological information as possible.
Ziyu Liao, Tao Liu, Yue He, Longlong Lin
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Abstract and Applied Analysis, 2014 Circulant matrices play an important role in solving ordinary and partial differential equations. In this paper, by using the inverse factorization of polynomial of degree n, the explicit determinants of circulant and left circulant matrix involving ...
Juan Li, Zhaolin Jiang, Fuliang Lu
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Factorizations of operator matrices
Linear Algebra and its Applications, 1995 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source