Results 81 to 90 of about 9,658 (265)

Holomorphic Factorization of Matrices of Polynomials [PDF]

, 1999
This paper considers some work done by the author and Catlin [CD1,CD2,CD3] concerning positivity conditions for bihomogeneous polynomials and metrics on bundles over certain complex manifolds. It presents a simpler proof of a special case of the main result in [CD3], providing also a self-contained proof of a generalization of the main result from [CD1]
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

On matrices associated to prime factorization of odd integers

Condensed Matter Physics, 2008
In this paper we introduce in section 5 integral matrices M(n) for any factorization of an odd integer n into r distinct odd primes. The matrices appear in several versions according to a parameter ρ∈[0,1], they have size 2r×2r and their rank satisfies e.
T. Bier
doaj   +1 more source

OCMA: Fast, Memory-Efficient Factorization of Prohibitively Large Relationship Matrices

G3: Genes, Genomes, Genetics, 2019
Matrices representing genetic relatedness among individuals (i.e., Genomic Relationship Matrices, GRMs) play a central role in genetic analysis. The eigen-decomposition of GRMs (or its alternative that generates fewer top singular values using genotype ...
Zhi Xiong, Qingrun Zhang, Alexander Platt, Wenyuan Liao, Xinghua Shi, Gustavo de los Campos, Quan Long   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effective Temporal Graph Learning via Personalized PageRank

Entropy
Graph representation learning aims to map nodes or edges within a graph using low-dimensional vectors, while preserving as much topological information as possible.
Ziyu Liao, Tao Liu, Yue He, Longlong Lin
doaj   +1 more source

Bidiagonal factoring of Stirling matrices

Maple Transactions
Stirling cycle numbers and Stirling partition numbers have many combinatorial applications. A symmetric matrix built from Stirling cycle numbers, which is known to be totally nonnegative, appears as https://oeis.org/A137854 in the Online Encyclopedia of Integer Sequences. In this paper we give analytical bidiagonal factorings of these matrices.
Robert M. Corless, David J. Jeffrey, Qingze Li   +2 more
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source