Results 231 to 240 of about 15,541,552 (290)

Key factors for an equitable health intervention for Black men with low income and chronic illness in a southern state in the United States. [PDF]

PLoS One
Marshall SA, Johnson O, Pro G, Williams A, Zaller N, Montgomery BEE.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Factors Influencing Perceived Multidisciplinary Team Meeting Effectiveness in Teams Addressing Work-Related Respiratory Diseases: A Qualitative Study. [PDF]

J Multidiscip Healthc
Boezeman EJ, Zipfel N, Franklin SW, Verheijen NM, van Snippenburg R, Proper KI, Schaafsma FG.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Let's be CLEAR: Cath Lab Evaluation of Atherosclerotic Risk is a disease modifying opportunity. [PDF]

Br J Cardiol
Cunneen B, O'Callaghan D, O'Callaghan C, O'Neill F, Loo B, Wheen P, Moore D, Mulcahy D, Armstrong R, Maher V.   +9 more
europepmc   +1 more source

Using tDCS to Investigate Fear Extinction in a Large Population of Healthy Volunteers

Brain Stimulation
Michael Nitsche, Yuanbo Ma, Giorgi Batzikadse, Fujia Jiao, Fatemeh Yavari   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Determinants of Nurses' Work Motivation in the Context of Sustainable Human Resource Management: A Study in a University Clinical Hospital in Poland. [PDF]

Healthcare (Basel)
Rybarczyk-Szwajkowska A, Krakowiak A, Strzelecka A, Rydlewska-Liszkowska I.   +3 more
europepmc   +1 more source

Human factors issues in Malaysian green building development: A review

, 2016
JawatanKuasa Kerja PSM Human Factors and Ergonomics Society Malaysia
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source