FAdV-4 induces more severe inflammatory responses compared to FAdV-8b [PDF]
Poultry ScienceMultiple infections, either single or mixed, involving pathogens such as serotype 4 fowl adenovirus (FAdV-4) and serotype 8b fowl adenovirus (FAdV-8b), have been observed in numerous laying hens in China, leading to severe liver damage.
Sidang Liu
exaly +7 more sources
A Novel Recombinant FAdV-4 Virus with Fiber of FAdV-8b Provides Efficient Protection against Both FAdV-4 and FAdV-8b [PDF]
Viruses, 2022 Since 2015, the outbreaks of hydropericardium-hepatitis syndrome (HHS) and inclusion body hepatitis (IBH) caused by the highly pathogenic serotype 4 fowl adenovirus (FAdV-4) and serotype 8 fowl adenovirus (FAdV-8), respectively, have caused huge economic
Hao Lu, Quan Xie, Zhehong Zhao
exaly +5 more sources
Microbiology Spectrum, 2023 Recently, the infection of fowl adenoviruses (FAdVs) in chicken flocks has caused huge economic losses to the poultry industry in China. Although immunization with Fiber protein can provide autogenous protection of FAdVs, no commercial multivalent ...
Tuofan Li, Zhimin Wan, Hongxia Shao
exaly +5 more sources
Coinfection with fowl adenovirus serotypes 1 and 4 (FAdV-1 and -4) enhances FAdV-4 replication through FAdV-1-mediated upregulation of HSPA2 expression [PDF]
VirulenceFowl adenoviruses (FAdVs) are widely distributed in poultry populations around the world, and many diseases are associated with FAdV infection in chickens.
Xiaoxuan Li +10 more
doaj +5 more sources
FAdV-4 without Fiber-2 Is a Highly Attenuated and Protective Vaccine Candidate
Microbiology Spectrum, 2022 Hepatitis-hydropericardium syndrome (HHS) caused by the highly pathogenic fowl adenovirus serotype 4 (FAdV-4) has resulted in huge economic losses to the poultry industry globally.
Quan Xie, Luyuan Li, Tuofan Li
exaly +5 more sources
Computational Identification of Natural Inhibitors Targeting Fiber Proteins of FAdV-1 and FAdV-4 Through Integrated Virtual Screening and Molecular Dynamics Simulations [PDF]
Veterinary SciencesFowl adenoviruses (FAdVs) represent a major threat to poultry health, with serotypes FAdV-1 and FAdV-4 causing adenoviral gizzard erosion (AGE) and hepatitis-hydropericardium syndrome (HHS), respectively.
Amina Kardoudi +5 more
doaj +4 more sources
FAdV-4 Promotes Expression of Multiple Cytokines and Inhibits the Proliferation of aHEV in LMH Cells
Viruses, 2023 Single or mixed infections of multiple pathogens such as avian hepatitis E virus (aHEV) and avian leukosis virus subgroup J (ALV-J) have been detected in numerous laying hens with severe liver injury in China. Thus, aHEV and immunosuppressive viruses are
Lidan Hou, Yawen Zhang, Zhang Yawen
exaly +5 more sources
Fiber-2, not Fiber-1, is the principal protective immunogen of fowl adenovirus serotype 4: insights from a comparative efficacy study of chimeric virus-based inactivated vaccines [PDF]
Poultry ScienceFowl adenovirus serotype 4 (FAdV-4) uniquely encodes two fiber proteins (fiber-1 and fiber-2), while FAdV-8b possesses only one. Although our previous study showed that an inactivated vaccine based on a chimeric virus with FAdV-4′s fiber-1 replaced by ...
Panpan Yang +14 more
doaj +2 more sources
A novel monoclonal antibody differentiates highly pathogenic serotype 4 fowl adenovirus through targeting 188R in the Hexon [PDF]
Poultry ScienceSince 2015, hepatitis-hydropericardium syndrome (HHS) induced by the infection of highly pathogenic serotype 4 fowl adenovirus (HP-FAdV-4) has caused severe economic losses to the poultry industry.
Ye Tang +13 more
doaj +2 more sources
Viruses, 2019 Fowl adenovirus serotype 4 (FAdV-4) causes hepatitis-hydropericardium syndrome (HHS), leading to severe economic losses in the poultry industry. Although the pathogenesis of FAdV-4 infection has caused much attention, the underlying molecular mechanisms ...
Junfeng Gao +2 more
exaly +3 more sources