Results 101 to 110 of about 8,833,991 (337)
BMC GenomicsBackground The precise mechanisms leading to the development of heart failure with preserved ejection fraction (HFpEF) remain incompletely defined. In this study, an integrative approach utilizing untargeted proteomics and metabolomics was employed to ...
Muyashaer Abudurexiti +6 more
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High‐Sensitivity Troponin: A Clinical Blood Biomarker for Staging Cardiomyopathy in Fabry Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundHigh‐sensitivity troponin (hs‐TNT), a biomarker of myocardial damage, might be useful for assessing fibrosis in Fabry cardiomyopathy. We performed a prospective analysis of hs‐TNT as a biomarker for myocardial changes in Fabry patients and a ...
Nora Seydelmann +11 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Intestinal FailureIntroduction: The occurrence of catheter related blood stream infection (CRBSI) is a leading cause of morbidity and mortality for patients receiving home parenteral support (HPS) via a central venous catheter (CVC), as part of their chronic intestinal ...
Ashley Bond +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Forecasting overhead distribution line failures using weather data and gradient-boosted location, scale, and shape models [PDF]
, 2022 Antoni M. Sieminski, Carl Donovan
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Correction: The role of RIPK1 mediated cell death in acute on chronic liver failure
Cell Death and Disease, 2022 Takayuki Kondo +13 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Psychometric properties of the MacNew heart disease health‐related quality of life instrument in patients with heart failure [PDF]
, 2008 Stefan Höfer +6 more
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