Results 91 to 100 of about 4,569,825 (258)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Correction: The role of RIPK1 mediated cell death in acute on chronic liver failure

Cell Death and Disease, 2022
Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan   +13 more
doaj   +1 more source

Prognostic Impact of Baseline Potassium Abnormalities in Patients with Heart Failure with Reduced Ejection Fraction: A Real-World Cohort Study

Medical Sciences
Introduction: Abnormal serum potassium levels are a common issue in patients with heart failure with reduced ejection fraction (HFrEF), limiting the use of prognostically beneficial therapies.
Alvaro Roldan-Guerra, Jorge Perea-Armijo, Rafael González-Manzanares, Juan Carlos Castillo-Domínguez, Manuel Crespin-Crespin, Manuel Pan-Álvarez Ossorio, Manuel Anguita-Sánchez, José López-Aguilera   +7 more
doaj   +1 more source

Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats

Scientific Reports, 2017
Portal hypertension (PH) is a major cause of morbidity and mortality in chronic liver disease. Infection and inflammation play a role in potentiating PH and pro-inflammatory cytokines, including TNF, are associated with severity of PH.
V. Balasubramanian, G. Mehta, H. Jones, V. Sharma, N. A. Davies, R. Jalan, R. P. Mookerjee   +6 more
doaj   +1 more source

Low triiodothyronine syndrome and selenium deficiency - undervalued players in advanced heart failure? A single center pilot study

BMC Cardiovascular Disorders, 2019
Background The function of deiodinases – selenoproteins converting thyroid hormones may be disturbed by oxidative stress accompanying heart failure. Selenium (Se) may be used by glutathione peroxidase, leading to a lack of deiodinase and triiodothyronine
Magdalena Fraczek-Jucha, Katarzyna Zbierska-Rubinkiewicz, Małgorzata Kabat, Krzysztof Plens, Radoslaw Rychlak, Jadwiga Nessler, Andrzej Gackowski   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Association between self-reported and objectively assessed physical functioning in the general population

Scientific Reports
Knowledge about a patient’s physical fitness can aid in medical decision-making, but objective assessment can be challenging and time-consuming. We aimed to investigate the concordance of self-reported health status and physical functioning with the 6 ...
Nicola Moser, Floran Sahiti, Götz Gelbrich, Vladimir Cejka, Fabian Kerwagen, Judith Albert, Stefan Frantz, Peter U. Heuschmann, Stefan Störk, Caroline Morbach   +9 more
doaj   +1 more source

Physical Activity and Heart Failure Risk in a Prospective Study of Men

, 2015
OBJECTIVES This study investigated if total physical activity, as well as different types of physical activity, were associated with heart failure risk. BACKGROUND Physical activity has shown to be associated with reduced risks of coronary heart disease ...
Orsini, Nicola,, Bellavia, A,, Rahman, Iffat,, Bellavia, Andrea,, Rahman, I, Orsini, N,, Wolk, A, Wolk, Alicja,   +7 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source