Results 71 to 80 of about 2,757,263 (268)

Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats

Scientific Reports, 2017
Portal hypertension (PH) is a major cause of morbidity and mortality in chronic liver disease. Infection and inflammation play a role in potentiating PH and pro-inflammatory cytokines, including TNF, are associated with severity of PH.
V. Balasubramanian, G. Mehta, H. Jones, V. Sharma, N. A. Davies, R. Jalan, R. P. Mookerjee   +6 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Correlation between mitochondrial DNA copy number, Klotho protein, myostatin and frailty in elderly patients with sarcopenia

Guoji laonian yixue zazhi
[Objective] To investigate the correlation of mitochondrial DNA copy number (mtDNAcn), Klotho protein, myostatin (MSTN) and their combination with physical frailty in elderly patients with sarcopenia.
Zhou Yanyan, Zhao Xulan, Zhang Shiyang, Xia Song, Zhang Junhui, Liang Fang   +5 more
doaj   +1 more source

Low triiodothyronine syndrome and selenium deficiency - undervalued players in advanced heart failure? A single center pilot study

BMC Cardiovascular Disorders, 2019
Background The function of deiodinases – selenoproteins converting thyroid hormones may be disturbed by oxidative stress accompanying heart failure. Selenium (Se) may be used by glutathione peroxidase, leading to a lack of deiodinase and triiodothyronine
Magdalena Fraczek-Jucha, Katarzyna Zbierska-Rubinkiewicz, Małgorzata Kabat, Krzysztof Plens, Radoslaw Rychlak, Jadwiga Nessler, Andrzej Gackowski   +6 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Sepsis severity in chronic intestinal failure patients presenting with catheter related blood stream infection

Intestinal Failure
Introduction: The occurrence of catheter related blood stream infection (CRBSI) is a leading cause of morbidity and mortality for patients receiving home parenteral support (HPS) via a central venous catheter (CVC), as part of their chronic intestinal ...
Ashley Bond, Maja Kopczynska, Antje Teubner, Arun Abraham, Jaclyn Salt, Maria Barrett, Simon Lal   +6 more
doaj   +1 more source

Failure? What Failure? [PDF]

, 2012
The characteristics of the maritime sector and the failures in maritime policy that are exhibited by it are analysed in some depth.
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Correction: The role of RIPK1 mediated cell death in acute on chronic liver failure

Cell Death and Disease, 2022
Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan   +13 more
doaj   +1 more source