Results 101 to 110 of about 4,569,825 (258)

Verification of failure mechanisms and design philosophy for a bolt-anchored and fibre-reinforced shotcrete lining

, 2020
Falling or sliding of loose blocks is one of the most common failure modes in a rock tunnel. For tunnels in hard and jointed rock, fibre-reinforced shotcrete (sprayed concrete) in combination with rock bolts is one of the most commonly used supports to ...
Sjölander, Andreas, Ansell, Anders, Sjölander, Andreas,, Ansell, Anders,, Hellgren, Rikard, Malm, Richard,, Malm, Richard, Hellgren, Rikard,   +7 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Machinery failure analysis and troubleshooting /

, 1997
This newly expanded edition discusses proven approaches to defining causes of machinery failure as well as methods for analyzing and troubleshooting failures.This newly expanded edition discusses proven approaches to defining causes of machinery failure ...
Geitner, Fred K., Bloch, Heinz P.
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Echocardiography in Heart Failure

, 2010
It is generally accepted that Doppler echocardiography is the mainstay investigation for the diagnosis and management of patients with heart failure.
Stellan Mörner, Henein, Michael Y., Per Lindqvist, Lindqvist, Per,, Michael Y. Henein, Morner, Stellan   +5 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Discharge AI-ECG-Derived Age and Incidence of Cardiac Allograft Vasculopathy at 3 Years: A Pilot Study

Journal of Cardiovascular Development and Disease
Cardiac allograft vasculopathy (CAV) remains a leading cause of graft failure after heart transplantation, yet an early, non-invasive risk stratification tool is not available.
Andrea Muniz, Yugant Khand, Vidit Yadav, Aarti Desai, Laxmi Raj Bangari, Surbhi Dadwal, Jose Ruiz, Devora Leventhal, Rohan Goswami   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Acute renal failure associated with nonfulminant hepatitis A virus infection

, 2002
Hepatitis A is usually a mild self-limiting infection of the liver. Nonfulminant acute renal failure very rarely complicates type A viral hepatitis.
Adas, M, Yarman, S, Alagol, F, Boztepe, H, Tanakol, R, Ecder, T   +5 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source