Results 61 to 70 of about 5,845,611 (294)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role of bridging nodes in behavioral network models of complex engineered systems

Design Science, 2018
Recent advances in early stage failure analysis approaches have introduced behavioral network analysis (BNA), which applies a network-based model of a complex engineered system to detect the system-level effect of ‘local’ failures of design variables and
Hannah S. Walsh, Andy Dong, Irem Y. Tumer   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Optimizing Retention Bunkers in Copper Mines with Numerical Methods and Gradient Descent

Applied Sciences
This study examines the optimization of ore receiving bins in underground copper mines, targeting the reduction of rapid wear and tear on bin components.
Piotr Bortnowski, Robert Król, Natalia Suchorab-Matuszewska, Maksymilian Ozdoba, Mateusz Szczerbakowicz   +4 more
doaj   +1 more source

Hardware-in-the-loop performance analysis of a railway traction system under sensor faults

The Journal of Engineering, 2019
Fault mode and effects analysis (FMEA) has been used during decades for analysing the effects of faults in different applications. Initially, FMEA based on risk priority numbers provided information about the effects in the system, but during the last ...
Fernando Garramiola, Javier Poza, Javier Poza, Jon del Olmo, Txomin Nieva   +4 more
doaj   +1 more source

A New Function-Topology-Based Method for Assessing Passive Safety of Mechatronics Systems

IEEE Access, 2020
Various safety assessment models for predicting the future state of systems based on online monitoring data have been proposed. However, the complexity and interdependencies of mechatronics systems make it improbable to predict and prevent all possible ...
Shuai Lin, Limin Jia, Yanhui Wang, Hengrun Zhang   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Approximate Bayesian Computation for a Dual-Failure-Modes Models and Its Application to Failure Times Data

IEEE Access
In this study, comprehensive approximate Bayesian computation (ABC) technique is explored, and develop for an innovative model. We practically demonstrate approximate Bayesian computation (ABC)-Gibbs scheme using Kolmogorov-Smirnov as distance function ...
Mustapha Muhammad, Badamasi Abba, Jinsen Xiao   +2 more
doaj   +1 more source