Results 141 to 150 of about 266,152 (301)
A failure criterion for fillet welds [PDF]
, 1981 The work constitutes a study of the strength of mild steel fillet welds subject to static loading, and the behaviour of flange welded beam-column connections under combined bending and shear. Tests are conducted on short welds in the as-welded and stress relieved conditions, and also on full-size beam-column connections.
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Failure criterion in the model of monoclinic elastic-plastic material
Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2016 The previously obtained defining relations for monoclinic elastic-plastic material are specified. The criterion of destruction is considered and procedure of its verification is offered.
O. L. Shved
doaj
DronesThe development of light composite rotor blades with acceptable load carrying capacity is an essential issue to be dealt with in the design of relatively large copter-type drones. In this paper, a method is established to determine the quasi-static blade
Chien Wei Jan, Tai Yan Kam
doaj +1 more source
Experimental Study and Failure Criterion Analysis on Combined Compression-Shear Performance of Self-Compacting Concrete. [PDF]
Materials (Basel), 2020 Jingrong W +3 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Failure criterion for two-ply plain-weave CFRP laminates
, 2013 We present an experimentally based failure criterion for symmetric two-ply plain-weave laminates of carbon fiber reinforced plastic. The criterion is formulated in terms of six force and moment stress resultants and consists of a set of three ...
Pellegrino, Sergio +1 more
core
Griffith Criterion for Brittle Fracture in Graphene
, 2015 There are prevailing concerns with the critical dimensions when conventional theories break down. Here we find that the Griffith criterion remains valid for cracks down to 10 rim but overestimates the strength of shorter cracks.
Fan FF +6 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source