Results 151 to 160 of about 266,152 (301)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Failure criterion for two-ply plain-weave CFRP laminates
, 2015 We present an experimentally based failure criterion for symmetric two-ply plain-weave laminates of carbon fiber reinforced plastic. The criterion is formulated in terms of six force and moment stress resultants and consists of a set of three ...
Mallikarachchi, HMYC, Pellegrino, S
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Failure as a criterion for medical school admission
Academic Medicine, 1980 D S, Greer, S M, Aronson
openaire +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Masonry failure criterion under biaxial stress state
, 2001 Asteris, PG, Syrmakezis, CA
core +1 more source
A bilinear failure criterion for mixed-mode delamination
, 1993 Many different failure criteria have been suggested for mixed-mode delamination toughness, but few sets of mixed-mode data exist that are consistent over the full range of Mode 1 opening load to Mode 2 shear load range.
Reeder, James R.
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
A general failure criterion for geomaterials with cross anisotropy
, 2011 The strength of soils and rocks is greatly influenced by cross anisotropy which cannot be properly characterized by an isotropic failure criterion. A novel anisotropic failure criterion is proposed for geomaterials in this paper.
Zhao, J. D., Gao, Z. W., Yao, Y. P.
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