Results 151 to 160 of about 4,757,745 (346)

Determining Quasi-Static Load Carrying Capacity of Composite Sandwich Rotor Blades for Copter-Type Drones

open access: yesDrones
The development of light composite rotor blades with acceptable load carrying capacity is an essential issue to be dealt with in the design of relatively large copter-type drones. In this paper, a method is established to determine the quasi-static blade
Chien Wei Jan, Tai Yan Kam
doaj   +1 more source

ANISAP: A three-dimensional finite element program for laminated composites subjected to mechanical loading [PDF]

open access: yes
ANISAP is a 3-D finite element FORTRAN 77 computer code for linear elastic, small strain, analysis of laminated composites with arbitrary geometry including free edges and holes.
Burns, S. W.   +2 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The effect of extreme temperatures on the elastic properties and fracture behavior of graphite/polyimide composites [PDF]

open access: yes
The influence of elevated and cryogenic temperatures on the elastic moduli and fracture strengths of several C6000/PMR-15 and C6000/NR-15082 laminates was measured. Tests were conducted at -157 C, 24 C, and 316 C (-250 F, 75 F, and 600 F).
Morris, D. H., Simonds, R. A.
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Delamination behavior of quasi-isotropic graphite epoxy laminates subjected to tension and torsion loads [PDF]

open access: yes
Sixteen and thirty-two ply quasi-isotropic laminates fabricated from AS4/3501-6 were subjected to pure tension, simultaneous tension and torsion, and torsion fatigue. Layups tested were (45 sub n/-45 sub n/O sub n/90 sub n) sub s, with n = 2 or 4.
Hinkley, J. A., Obrien, T. K.
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

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