Results 131 to 140 of about 4,757,745 (346)
A New Approach to Fibrous Composite Laminate Strength Prediction [PDF]
A method of predicting the strength of cross-plied fibrous composite laminates is based on expressing the classical maximum-shear-stress failure criterion for ductile metals in terms of strains.
Hart-Smith, L. J.
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Orthotropic failure criterion for timber
, 1994 Timber is an organic, orthotropic material of which the strength is currently not fully utilised in structural designs. Most design codes treat timber as an isotropic material with special clauses to compensate for the weaker strength across the grain. Several safety factors are used to accommodate the large variations in the strength of timber. In the
Haasbroek, D.F., Pretorius, L.
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Revista IBRACON de Estruturas e MateriaisThe experimental results of testing structures or structural parts are limited and, sometimes, difficult to interpret. Thus, the development of mathematical-numerical models is needed to complement the experimental analysis and allow the generalization ...
L. A. F. de Souza, R. D. Machado
doaj +1 more source
Correlation and shear bands in a plastically deformed granular medium
, 2017 Recent experiments (Le Bouil et al., Phys. Rev. Lett., 2014, 112, 246001) have analyzed the statistics of local deformation in a granular solid undergoing plastic deformation.
Barrat, Jean-Louis, Karimi, Kamran
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Finite element models for predicting crack growth characteristics in composite materials [PDF]
Two dimensional and quasi-three dimensional, linear elastic finite element models for the prediction of crack growth characteristics, including crack growth direction, in laminated composite materials are presented.
Buczek, M. B., Herakovich, C. T.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source