Results 121 to 130 of about 266,152 (301)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An anisotropic failure criterion for geomaterials
, 2011 The strength of geomaterials is strongly influenced by their fabric anisotropy, which can not be characterized by the isotropic failure criterion reasonably. A general anisotropic failure criterion is proposed.
Gao, Zhi Wei +2 more
core
Tensor Polynomial Failure Criterion: Coefficient Limits Based on Convexity Requirements
, 1997 The tensor polynomial failure criterion is a widely used tool for predicting failure of unidirectional composite lamina. Typically, the tensor polynomial failure criterion is used in the quadratic form, commonly referred to as the Tsai-Wu failure ...
Donald H. Koedam, Mark V. Bower
core +1 more source
True triaxial test and failure criterion of coal gangue concrete
Meitan xuebaoIn view of the pollution caused by the large storage of coal gangue and the shortage of natural aggregate in concrete, using coal gangue as coarse aggregate is a reasonable way to solve the above problems.
Weiping ZHAO +5 more
doaj +1 more source
A Reliable Fracture Angle Determination Algorithm for Extended Puck's 3D Inter-Fiber Failure Criterion for Unidirectional Composites. [PDF]
Materials (Basel), 2021 Gong Y +5 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2015 Assessments of inhomogeneous rock slope stability between Hoek-Brown failure criterion and Mohr-Coulomb failure ...
ZG Qian (14544029) +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Revista IBRACON de Estruturas e MateriaisThe experimental results of testing structures or structural parts are limited and, sometimes, difficult to interpret. Thus, the development of mathematical-numerical models is needed to complement the experimental analysis and allow the generalization ...
L. A. F. de Souza, R. D. Machado
doaj +1 more source