Predicting failure of specimens with either surface cracks or corner cracks at holes [PDF]
A previously developed fracture criterion was applied to fracture data for surface-cracked specimens subjected to remote tensile loading and for specimens with a corner crack (or cracks) emanating from a circular hole subjected to either remote tensile ...
Newman, J. C., Jr.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Failure Criterion‐Based Bead Optimization of a Wind Turbine Blade Root Section
Wind EnergyThis study presents a bead‐based optimization framework for fiber composite wind turbine blades, employing the Tsai–Wu failure criterion as the structural performance measure.
Philipp Ulrich Haselbach +4 more
doaj +1 more source
An Innovative Failure Criterion for Metal Cylindrical Shells under Explosive Loads. [PDF]
Materials (Basel), 2022 Li Y, Wang W, Chen Z.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Numerical and Experimental Studies for Fatigue Damage Accumulation of CFRP Cross-Ply Laminates Based on Entropy Failure Criterion. [PDF]
Materials (Basel), 2022 Deng H +5 more
europepmc +1 more source
Failure criterion of glass fabric reinforced plastic laminates [PDF]
Failure criteria are derived for several modes of failure (in unaxial tensile or compressive loading, or biaxial combined tensile-compressive loading) in the case of closely woven plain fabric, coarsely-woven plain fabric, or roving glass cloth ...
Haga, O., Hayashi, N., Kasuya, K.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Performance Assessment of Self-Healing Polymer-Modified Bitumens by Evaluating the Suitability of Current Failure Definition, Failure Criterion, and Fatigue-Restoration Criteria. [PDF]
Materials (Basel), 2023 Lv S +11 more
europepmc +1 more source
TNT equivalency study for space shuttle (EOS). Volume 1: Management summary report [PDF]
The existing TNT equivalency criterion for LO2/LH2 propellant is reevaluated. It addresses the static, on-pad phase of the space shuttle launch operations and was performed to determine whether the use of a TNT equivalency criterion lower than that ...
Wolfe, R. R.
core +1 more source