Results 91 to 100 of about 4,007,583 (304)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A temperature- and stress-controlled failure criterion for ice-filled permafrost rock joints

open access: yesThe Cryosphere, 2018
. Instability and failure of high mountain rock slopes have significantly increased since the 1990s coincident with climatic warming and are expected to rise further. Most of the observed failures in permafrost-affected rock walls are likely triggered by
Philipp Mamot   +3 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Critical Analysis of “Maximum Stress Failure Criterion” for Composite Materials

open access: yesThe Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2009
The paper deals with critical considerations upon different points of view that were enounced by some authors referring to Maximum Stress Failure Criterion for composite materials. The considerations stem both from a comparative analysis of the mentioned
Ion FUIOREA, Dumitriţa STĂNICĂ
doaj  

Integration and Application of a Fabric-Based Modified Cam-Clay Model in FLAC3D

open access: yesGeosciences
In order to consider the effect of fabric anisotropy in the analysis of geotechnical boundary value problems, this study proposes a modified model based on a fabric-based modified Cam-clay model, which can account for the anisotropic response of soil ...
Xiao-Wen Wang   +5 more
doaj   +1 more source

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