Results 91 to 100 of about 4,757,745 (346)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Frontiers in Built EnvironmentTensile membrane action (TMA) could significantly enhance the ultimate bearing capacity of reinforced concrete (RC) simply supported slabs under fire conditions.
Yan Jia +8 more
doaj +1 more source
And so on: two theories of regress arguments in philosophy [PDF]
, 2013 This PhD dissertation is on infinite regress arguments in philosophy. Its main goals are to explain what such arguments from many distinct philosophical debates have in common, and to provide guidelines for using and evaluating them.
Wieland, Jan Willem
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A New Criterion for Judging Tunnel Failure by the Strength Reduction Method
Applied SciencesRecently, the application of the strength reduction method (SRM) to tunnel stability research has become a trend. The failure criteria for the SRM in tunnels often draw from those used in slopes.
Chengya Hua, Chenguang Song, Leihua Yao
doaj +1 more source
Plane-stress fracture of compact and notch-bend specimens [PDF]
Thin-gaged or high toughness materials containing cracks usually fail in a ductile manner with nominal failure stresses approaching the ultimate strength of the material. For such materials, a two-parameter fracture criterion was developed.
Newman, J. C., Jr.
core +1 more source
Finite Element Analysis of FRP Debonding Failure at the Tip of Flexural/Shear Crack in Concrete Beam [PDF]
, 2013 One of the most common failure modes of strengthened RC beams with externally bonded FRP is intermediate crack (IC) debonding of FRP initiated at the tip of flexural/shear cracks. This study presents a method, using extended finite element method (XFEM),
Harries, Kent +2 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A new mixed mode I/II failure criterion for laminated composites considering fracture process zone
Theoretical and applied fracture mechanics (Print), 2018 In this paper, by considering the absorbed energy in the fracture process zone and extension of the minimum strain energy density theory for orthotropic materials, a new mixed mode I/II failure criterion was proposed.
Z. Daneshjoo +3 more
semanticscholar +1 more source