Results 61 to 70 of about 233,228 (266)
Frontiers in Built EnvironmentTensile membrane action (TMA) could significantly enhance the ultimate bearing capacity of reinforced concrete (RC) simply supported slabs under fire conditions.
Yan Jia +8 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
A New Criterion for Judging Tunnel Failure by the Strength Reduction Method
Applied SciencesRecently, the application of the strength reduction method (SRM) to tunnel stability research has become a trend. The failure criteria for the SRM in tunnels often draw from those used in slopes.
Chengya Hua, Chenguang Song, Leihua Yao
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Research on Calculation of Load-Bearing Capacity of Deepwater Umbilical Termination Head
Shiyou jixie, 2023 The umbilical termination head(UTH)is a key hardware device of underwater umbilicals.It bears complex loads in the harsh deepwater environment and has higher requirements for the reliability of the connection system.In this paper,the deepwater UTH used ...
Liu Xinyu +6 more
doaj
Failure Criteria of Gas-Infiltrated Sandy Shale Based on the Effective Stress Principle
Energies, 2016 Pore gas has a significant influence on rock strength. This study performed triaxial compression tests of gas-infiltrated sandy shale samples to investigate the strength characteristics under gas pressures of 0 and 2 MPa. The effective stress coefficient
Wenpu Li, Dongming Zhang, Minghui Li
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Failure assessment of a woven E-glass/vinyl ester composite subjected to large deformation loading
Science and Engineering of Composite Materials, 2012 Woven polymer-based composites exhibit highly non-linear behavior, which often results in very high strains to failure. A micromechanical model is developed to represent the large deformation kinematics of woven composites, and develop predictions for ...
Hufner David R. +2 more
doaj +1 more source