Results 71 to 80 of about 1,060,769 (255)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Plane Stress Failure Criterion for Inorganically-Bound Core Materials. [PDF]
Materials (Basel), 2021 Lechner P +3 more
europepmc +1 more source
Algorithms for Replica Placement in High-Availability Storage
, 2015 A new model of causal failure is presented and used to solve a novel replica placement problem in data centers. The model describes dependencies among system components as a directed graph. A replica placement is defined as a subset of vertices in such a
J Kim +5 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Reliable Fracture Angle Determination Algorithm for Extended Puck's 3D Inter-Fiber Failure Criterion for Unidirectional Composites. [PDF]
Materials (Basel), 2021 Gong Y +5 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Orthotropic failure criterion for timber
, 1994 Timber is an organic, orthotropic material of which the strength is currently not fully utilised in structural designs. Most design codes treat timber as an isotropic material with special clauses to compensate for the weaker strength across the grain. Several safety factors are used to accommodate the large variations in the strength of timber. In the
Haasbroek, D.F., Pretorius, L.
openaire +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
3D behaviour of a 4 parameter isotropic nonlinear hardening plasticity model for concrete [PDF]
, 2009 In general, concrete is a highly nonlinear material with great dependence on the confining stresses, a type of behaviour also common in other granular and quasi-brittle materials.
Barros, Joaquim A. O., Pereira, E. N. B.
core