Results 71 to 80 of about 931,469 (314)

Experimental investigation on the damage evolution and failure mechanism of segmental joints based on DOFS and AE

, 2023
Wenqi Guo, Kun Feng, Xuanyi Lu, Meilin Qi, Chuan He, Mingqing Xiao, Leibin Zuo   +6 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

Signal Transduction and Targeted Therapy, 2023
Leili Jia, Haihua Luo, Lizhong Li, Mingyao Wang, Jiangfeng Liu, Yuan Liang, Shan Li, Yong Jiang, Juntao Yang, Hongbin Song   +9 more
doaj   +1 more source

Damage evolution and fracture characteristics of coal rock impacted by self‐excited pulse water jet under different stress loading conditions

Energy Science & Engineering
In this paper, based on smoothed‐particle hydrodynamics‐finite element method, numerical models of plunger squeezing water at a sinusoidal velocity were established to simulate self‐excited pulse water jet (SEPWJ).
Hongyu Ma, Wen Wan, Dongfang Xu, Pengtao Zhao, Jiaokun Wu, Yong Chen, Yao Wang   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dynamic Relaxation Method for Load Capacity Analysis of Reinforced Concrete Elements

Applied Sciences, 2018
In this paper, an analysis method for the nonlinear behavior of reinforced concrete elements subjected to short-term static loads is proposed. The range of inelastic properties for the structural materials is considered, and the deformation processes of ...
Anna Szcześniak, Adam Stolarski
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The Impact of Temperature on the Performance and Reliability of Li/SOCl₂ Batteries

Energies
The performance and reliability of lithium thionyl chloride (Li/SOCl2) batteries are significantly affected by temperature, but the reliability level and failure mechanisms of Li/SOCl2 batteries remain unclear.
Yongquan Sun, Xinkun Qin, Lin Li, Youmei Zhang, Jiahai Zhang, Jia Qi   +5 more
doaj   +1 more source