Results 61 to 70 of about 7,431,248 (353)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Effect of Stress Triaxiality on Plastic Damage Evolution and Failure Mode for 316L Notched Specimen
Metals, 2019 To reveal the effect of stress triaxiality on plastic damage evolution and failure mode, 316L notched specimens with different notch sizes are systematically investigated by digital image correlation (DIC) observation, plastic damage analysis by finite ...
Peng, Wang, Dai, Liu, Zhang
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Applied Sciences, 2020 Under coupled compression–shear loading, the failure and instability behavior of inclined pillars is different from that of horizontal pillars. To enhance the reliability and accuracy of pillar strength design, the influence of different inclination ...
Yanlong Chen +5 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Research on the Failure Mode of Buried Pipeline under Impact Load
Shiyou jixie, 2020 In order to understand the failure modes of pipelines under different parameters, The numerical model established by the finite element software ABAQUS is used to simulate and calculate the plastic region distribution, peak stress and deformation of ...
白冰洁, 黄子川, 杜国峰
doaj
Output power limitations and improvements in passively mode locked GaAs/AlGaAs quantum well lasers [PDF]
, 2012 We report a novel approach for increasing the output power in passively mode locked semiconductor lasers. Our approach uses epitaxial structures with an optical trap in the bottom cladding that enlarges the vertical mode size to scale the pulse ...
Bryce, A.C. +3 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
ULTIMATE STRENGTH, DUCTILITY, AND FAILURE MODE OF HIGH-STRENGTH FRICTIONAL BOLTED JOINTS MADE OF HIGH-STRENGTH STEEL [PDF]
, 2023 Zice Qin +38 more
openalex +1 more source
Lifetime evaluation of concrete structures under sustained post-peak loading [PDF]
, 2005 Experimental tests on crack propagation in concrete under constant post-peak loading are simulated using the finite element method and the cohesive crack model, in both Mode I and Mixed-mode conditions.
Barpi, Fabrizio, Valente, Silvio
core +2 more sources