Results 61 to 70 of about 1,659,508 (308)

Study on Mechanical Properties and Cracking Mode of Coal Samples under Compression–Shear Coupled Load Considering the Effect of Loading Rate

Applied Sciences, 2020
Under coupled compression–shear loading, the failure and instability behavior of inclined pillars is different from that of horizontal pillars. To enhance the reliability and accuracy of pillar strength design, the influence of different inclination ...
Yanlong Chen, Huidong Cui, Hai Pu, Peng Wu, Liang Chen, Kai Zhang   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Research on the Failure Mode of Buried Pipeline under Impact Load

Shiyou jixie, 2020
In order to understand the failure modes of pipelines under different parameters, The numerical model established by the finite element software ABAQUS is used to simulate and calculate the plastic region distribution, peak stress and deformation of ...
白冰洁, 黄子川, 杜国峰
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Investigation on ultimate strength of thin wall tee pipe for sodium cooled fast reactor under seismic loading

Mechanical Engineering Journal, 2016
It is important to investigate the failure mode and ultimate strength of piping components in order to evaluate the seismic integrity of piping. Many failure tests of thick wall and high pressure piping for Light Water Reactors (LWRs) have been ...
Tomoyoshi WATAKABE, Kazuyuki TSUKIMORI, Akihito OTANI, Makoto MORIIZUMI, Naoaki KANEKO   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Tensile failure criteria for fiber composite materials [PDF]

The analysis provides insight into the failure mechanics of these materials and defines criteria which serve as tools for preliminary design material selection and for material reliability assessment. The model incorporates both dispersed and propagation
Rosen, B. W., Zweben, C. H.
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Uniaxial Compression Test and Numerical Study on the Mechanical Mechanism of Crack Exhibition and Propagation in Layered Rocks

Applied Sciences
Layered rocks are widely distributed in mining and underground engineering. The evolution processes, such as crack initiation, development and penetration, inevitably occur due to stress changes.
Zhengnan Zhang, Xiangxin Liu, Bin Gong, Zhengzhao Liang, Xianxian Liu, Xun You   +5 more
doaj   +1 more source