Results 51 to 60 of about 1,246,486 (311)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Optimisation of shock absorber process parameters using failure mode and effect analysis and genetic algorithm [PDF]

, 2013
The various process parameters affecting the quality characteristics of the shock absorber during the process were identified using the Ishikawa diagram and by failure mode and effect analysis.
Arokiasamy Mariajayaprakash, Krishnapillai Vivekananthan, Thiyagarajan Senthilvelan   +2 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

FMEA (FAILURE MODE AND EFFECTS ANALYSIS) AND PROPOSAL OF RISK MINIMIZING IN STORAGE PROCESSES FOR AUTOMOTIVECLIENT [PDF]

Acta Logistica, 2016
There are several quality tools that support achievement of goals and ensure primary basis for promoting quality in enterprises. FMEA is a quantitative inductive method, which was created for the recognizing and evaluating of products ...
Kristína Ignáczová
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

FMEA and FTA Analyses of the Adhesive Joining Process using Electrically Conductive Adhesives [PDF]

, 2017
This paper introduces a formulation of appropriate risk estimation methods that can be used for improving of processes in the electronics area. Two risk assessment methods have been chosen with regard to the specifics of adhesive joining based on ...
Mach , P., Povolotskaya , E.
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Quality Analysis of Crude Palm Oil Using Free Fatty Acid Content Parameters with Failure Mode and Effect Analysis

Engineering Proceedings
Competition in the industry forces palm oil producers to keep raising the caliber of their output. One of the businesses involved in the Crude Palm Oil sector is PT. XYZ. The quality of the CPO that PT. XYZ produces is a top priority.
Nismah Panjaitan, Muhammad Zaky Faris, Juni Arta Lubis, Niken Kristin Silitonga   +3 more
doaj   +1 more source

Failure Mode and Effect Analysis of Subsea Multiphase Pump Equipment

MATEC Web of Conferences, 2014
Finding oil and gas reserves in deep/harsh environment with challenging reservoir and field conditions, subsea multiphase pumping benefits has found its way to provide solutions to these issues.
Oluwatoyin Shobowale Kafayat, Hashim Fakhruldin Mohd, Hussin Hilmi Bin   +2 more
doaj   +1 more source