Results 61 to 70 of about 289,433 (344)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Mitigating the impacts of COVID-19: failure mode and effect analysis and supply chain resilience (FMEA-SCR) combined model

open access: yesModern Supply Chain Research and Applications, 2023
PurposeThe coronavirus disease (COVID-19) pandemic generated a worldwide financial crisis by impacting several links of the supply chain, however companies can take advantage by quantitatively measuring the disruptive impacts.Design/methodology ...
Antonio Marco-Ferreira   +3 more
semanticscholar   +1 more source

FMEA (FAILURE MODE AND EFFECTS ANALYSIS) AND PROPOSAL OF RISK MINIMIZING IN STORAGE PROCESSES FOR AUTOMOTIVECLIENT [PDF]

open access: yesActa Logistica, 2016
There are several quality tools that support achievement of goals and ensure primary basis for promoting quality in enterprises. FMEA is a quantitative inductive method, which was created for the recognizing and evaluating of products ...
Kristína Ignáczová
doaj   +1 more source

Failure mode analysis on concentrated solar power (CSP) plants : a case study on solar tower power plant

open access: yes, 2016
This thesis is an investigation of critical failure modes of solar tower power system in concentrated solar power (CSP) technology. The thesis evaluated the causes and impacts of failure on the major components and apply the failure Mode and Effect ...
Avapak, Sukunta
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mode I fracture evaluation of carbon fiber reinforced polymer/steel interfaces subject to freeze-thaw cycling

open access: yes, 2020
In order to increase the durability database and have a better understanding of the degradation mechanism, the effect of freeze-thaw cycling on the mode I fracture energy release rate of CFRP (Carbon Fiber Reinforced Polymer)/steel interface is studied ...
Wang, Xiaomeng, Petrů, Michal
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

A practical framework based on Fuzzy FMEA to diagnose causes of delay in construction projects [PDF]

open access: yesMuṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2017
Nowadays, most of developed and developing countries, because of both limited resources and growing competitive markets, looking for to diagnose the causes of projects delay and are trying to develop solutions for decreasing amount of delay in next ...
Hiwa Farughi   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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