Results 61 to 70 of about 1,270,105 (343)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Enhance maintenance problem recognition techniques and its application to palm oil mills [PDF]
, 2008 This paper discusses the application of enhanced maintenance problem recognition techniques. The main contribution of this study is the proposed combined techniques, namely snapshot model, failure mode, effect and criticality analysis (FMECA), Pareto ...
Asmai, S.A. +2 more
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FMEA (FAILURE MODE AND EFFECTS ANALYSIS) AND PROPOSAL OF RISK MINIMIZING IN STORAGE PROCESSES FOR AUTOMOTIVECLIENT [PDF]
Acta Logistica, 2016 There are several quality tools that support achievement of goals and ensure primary basis for promoting quality in enterprises. FMEA is a quantitative inductive method, which was created for the recognizing and evaluating of products ...
Kristína Ignáczová
doaj +1 more source
Redesign Pelayanan Farmasi dengan Metode Failure Mode And Effect Analysis [PDF]
, 2011 Background: Pharmacy service is a high risk area in thesupport of health service quality. PKU Muhammadiyah Hospitalis a hospital that respons to systematic movement in servicesthat focus on patient safety such as minimizing the incidenceof medication ...
Supriyanti, E. (Eri)
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
IEEE Transactions on Reliability, 2019 Failure mode and effect analysis (FMEA) is an effective risk-management tool, which has been extensively utilized to manage failure modes (FMs) of products, processes, systems, and services. Almost all FMEA models are concerned with how to get a complete
Hengjie Zhang +3 more
semanticscholar +1 more source