Results 71 to 80 of about 296,075 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Failure Mode and Effect Analysis in a Linguistic Context: A Consensus-Based Multiattribute Group Decision-Making Approach

IEEE Transactions on Reliability, 2019
Failure mode and effect analysis (FMEA) is an effective risk-management tool, which has been extensively utilized to manage failure modes (FMs) of products, processes, systems, and services. Almost all FMEA models are concerned with how to get a complete
Heng-Jie Zhang, Yucheng Dong, Iván Palomares-Carrascosa, Hai-Wei Zhou   +3 more
semanticscholar   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Failure Mode and Effect Analysis using Soft Set Theory and COPRAS Method

International Journal of Computational Intelligence Systems, 2017
Failure mode and effect analysis (FMEA) is a risk management technique frequently applied to enhance the system performance and safety. In recent years, many researchers have shown an intense interest in improving FMEA due to inherent weaknesses ...
Ze-Ling Wang, Jian-Xin You, Hu-Chen Liu, Song-Man Wu   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Quality Control Analysis Using the Failure Mode and Effect Analysis Method

Procedia of Engineering and Life Science
This study aimed to investigate critical factors contributing to defective Epodion® rh-Erythropoietin Alfa syringes, specifically focusing on reducing cracks during manufacturing.
M. L. Hakim, A. Cahyana
semanticscholar   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

PENERAPAN METODE FMEA DAN AHP DALAM PERUMUSAN STRATEGI PENGELOLAAN RESIKO PROSES PRODUKSI YOGHURT

Jurnal Teknologi Pertanian, 2017
ABSTRAK Analisis risiko produksi merupakan aspek penting dalam menjamin keberhasilan produksi dan bisnis. Riset ini bertujuan menganalisis risiko produksi yoghurt, mengidentifikasi faktor-faktor yang menyebabkan terjadinya risiko produksi yoghurt, dan ...
Muchlis Dwi Prasetiyo, Imam Santoso, Siti Asmaul Mustaniroh, Purwadi Purwadi   +3 more
doaj   +1 more source

An Improved Failure Mode Effects Analysis for Hospitals

Archives of Pathology & Laboratory Medicine, 2004
Abstract Objective. —To review the Failure Mode Effects Analysis (FMEA) process recommended by the Joint Commission on Accreditation of Health Organizations and to review alternatives. This reliability engineering tool may be unfamiliar to hospital personnel.
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source