Results 91 to 100 of about 253,748 (293)

MOD-2 Failure Mode and Effects Analysis

, 1979
The results of a failure mode and effects analysis of the Mod-2 wind turbine are ...
Lynette, R., Poore, R.
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Clinical Risk Assessment of Intensive Care Unit using Failure Mode and Effects Analysis

بیمارستان, 2015
Background: The goal of clinical risk management is to improve the quality of health care organization’s services and to ensure patientschr('39') safety.
Farnaz Attar Jannesar Nobari, Taraneh Yousefinezhadi, Faranak Behzadi Goodari, Mohammad Arab   +3 more
doaj  

A novel decision-making approach for risk assessment of converter steelmaking process based on fuzzy DEMATEL method

Alexandria Engineering Journal
Converter steelmaking is a critical process in steel production, facing various failure modes with severe safety and operational risks. However, comprehensive risk assessments in this area remain limited.
Fei Gao, Ding Zhou
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Finite element analysis of the ECT test on mode III interlaminar fracture of carbon-epoxy composite laminates

, 2006
In this work a parametric study of the Edge Crack Torsion (ECT) specimen was performed in order to maximize the mode III component (GIII) of the strain energy release rate for carbon-epoxy laminates.
Morais, A. B. de, Moura, M. F. S. F. de, Morais, J. J. L., Silva, M. A. L.   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Risk Factor Assessment in a Carpet Manufacturing Company Using the Failure Modes and Effects Analysis in Mazandaran

تحقیقات سلامت در جامعه, 2019
Introduction and purpose: The most prevalent accidents and injuries occur in industries. Risk assessment and risk management are the basis for planning to provide solutions and control hazards.
solale ramzani, mirtaghi mirmohammadi
doaj  

Production Improvement through Fixture Design: A Case Study of an Agricultural Machinery Parts Manufacturer

RMUTL Engineering Journal
This case study focuses on a manufacturing company producing agricultural machinery parts. The company faced a significant challenge: it could not meet customer demand due to inefficiencies in the production process.
Bhoomboon Phontang, Jetnipat Pimollukanakul, Thamrong Gearam, Jittiwat Nithikarnjanatharn, Supattra Muparang, Wannisa Nutkhum   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source