Results 71 to 80 of about 1,193,680 (335)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Space tug propulsion system failure mode, effects and criticality analysis [PDF]

For purposes of the study, the propulsion system was considered as consisting of the following: (1) main engine system, (2) auxiliary propulsion system, (3) pneumatic system, (4) hydrogen feed, fill, drain and vent system, (5) oxygen feed, fill, drain ...
Boyd, J. W., Hardison, E. P., Heard, C. B., Orourke, J. C., Osborne, F., Wakefield, L. T.   +5 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Risk Assessment for Failure Mode and Effects Analysis Using the Bonferroni Mean and TODIM Method

Mathematics, 2019
As a safety and reliability analysis technique, failure mode and effects analysis (FMEA) has been used extensively in several industries for the identification and elimination of known and potential failures.
Jianghong Zhu, Bin Shuai, Rui Wang, Kwai-Sang Chin   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Risk Assessment of the Processes of Operating Room Department using the Failure Mode and Effects Analysis (FMEA) Method

بیمارستان, 2017
Background: Reduction of errors is necessary to improve the quality of healthcare, promoting communication between the hospital staff and patients, and decreasing the patientchr('39')s complaints in hospitals.
Zahra Kavosi, Fateme Setoodehzadeh, Mozhgan Fardid, Maryam Gholami, Marzie Khojastefar, Mahbube Hatam, Zahra tahiati, Gholamreza Fardid   +7 more
doaj  

Independent Orbiter Assessment (IOA): Analysis of the life support and airlock support subsystems [PDF]

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality ...
Arbet, Jim, Barickman, K., Duffy, R., Saiidi, Mo J.   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Novel Method for Failure Mode and Effect Analysis Based on the Fermatean Fuzzy Set and Bonferroni Mean Operator

Machines
Failure mode and effects analysis (FMEA) helps to identify the weak points in the processing, manufacturing, and assembly of products and plays an important role in improving product reliability.
Liangsheng Han, Mingyi Xia, Yang Yu, Shuai He   +3 more
doaj   +1 more source

Effectiveness Of Failure Modes Effect Analysis (FMEA)

Journal of Indonesian Health Policy and Administration, 2017
Objective : One of the prevention efforts of medical errors that occur in health services is by identifying the potential failure of the service before the failure occurs. FMEA is one way to identify the risks of failure. Therefore, the authors wanted to find out whether FMEA was effective for reducing Medical error based on previous studies.Method ...
Putri Ingen Setiasih, Purnawan Junadi
openaire   +2 more sources