Results 51 to 60 of about 262,049 (253)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Risk Assessment of the Processes of Operating Room Department using the Failure Mode and Effects Analysis (FMEA) Method

بیمارستان, 2017
Background: Reduction of errors is necessary to improve the quality of healthcare, promoting communication between the hospital staff and patients, and decreasing the patientchr('39')s complaints in hospitals.
Zahra Kavosi, Fateme Setoodehzadeh, Mozhgan Fardid, Maryam Gholami, Marzie Khojastefar, Mahbube Hatam, Zahra tahiati, Gholamreza Fardid   +7 more
doaj  

Risk Assessment for Failure Mode and Effects Analysis Using the Bonferroni Mean and TODIM Method

Mathematics, 2019
As a safety and reliability analysis technique, failure mode and effects analysis (FMEA) has been used extensively in several industries for the identification and elimination of known and potential failures.
Jianghong Zhu, Bin Shuai, Rui Wang, Kwai-Sang Chin   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Novel Method for Failure Mode and Effect Analysis Based on the Fermatean Fuzzy Set and Bonferroni Mean Operator

Machines
Failure mode and effects analysis (FMEA) helps to identify the weak points in the processing, manufacturing, and assembly of products and plays an important role in improving product reliability.
Liangsheng Han, Mingyi Xia, Yang Yu, Shuai He   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Maintenance Analysis of Raw Mill Machines in Cement Production

Engineering Proceedings
PT X is one of the companies that produces cement in Indonesia. Engine breakdowns do happen occasionally in raw mill machines in PT X. This study analyzed the cause of occasional breakdowns.
Aditya Chandra Nugroho, Taurista Perdana Syawitri, Rafi Miftachul An’am   +2 more
doaj   +1 more source