Results 61 to 70 of about 1,193,680 (335)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The xSAP Safety Analysis Platform [PDF]
, 2015 This paper describes the xSAP safety analysis platform. xSAP provides several model-based safety analysis features for finite- and infinite-state synchronous transition systems.
A Joshi +15 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
New method for critical failure prediction of complex systems [PDF]
, 1968 Rigorous analytical technique, called criticality determination methodology /or CD technique/ determines the probability that a given complex system will successfully achieve stated objectives.
Cox, C. T. +3 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Application of failure mode and effects analysis in ecology in Russia
MATEC Web of Conferences, 2018 The article presents a comprehensive review of the FMEA analysis (the failure modes and effects analysis) in the construction industry in the Russian Federation and suggests the same analysis, which can be applied to ecological issues. The paper analyzes
Borkovskaya Victoria, Passmore David
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Risk Evaluation in Failure Mode and Effects Analysis Based on D Numbers Theory
International Journal of Computers Communications & Control, 2019 Failure mode and effects analysis (FMEA) is a useful technology for identifying the potential faults or errors in system, and simultaneously preventing them from occurring. In FMEA, risk evaluation is a vital procedure.
B. Liu, Yong Deng
semanticscholar +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Procedure for Failure Mode, Effects, and Criticality Analysis (FMECA) [PDF]
This document provides guidelines for the accomplishment of Failure Mode, Effects, and Criticality Analysis (FMECA) on the Apollo program. It is a procedure for analysis of hardware items to determine those items contributing most to system unreliability
core +1 more source