Results 111 to 120 of about 253,748 (293)
Reliability failure mode, effects, and criticality analysis : addendum 1; HFE [PDF]
, 1971 This addendum is an update to 501 B for Heat Flow Experiment (HFE), Array A-2, D, E. Contained in this addendum is the discussion of the changes and the updated Failure Mode, Effects and Criticality Analysis (FMECA) Work Sheets.prepared by R.W. Hiebert.B-
Hiebert, Robert W.
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Sequential Effects in Failure Mode Analysis [PDF]
, 1974 In systems which involve sequential control, standby safety systems, and safety shut down procedures, the sequence of actions is important in describing normal operation.
Taylor, J. R., Taylor, J.R.
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2014 Failure mode effects analysis (FMEA) for the different MEB, ALB and TNZ drug product quality attributes.
Zeleke Mekonnen (226283) +9 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Caracterização e controle do defeito ocasionado pelo uso do fonolito em massas ceramicas gres [PDF]
, 1996 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoEstudo e caracterização de um defeito identificado em produtos cerâmicos de pavimento esmaltado tipo grês, estando a sua ocorrência relacionada com a utilização do ...
Mussolin, Simone Monte-Mor
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Fracture mechanisms and failure criteria of adhesive joints and toughened epoxy adhesives
, 2010 PhDAdhesive bonded applications are used widely in industry because of significant advantages such as uniform stress distribution, and the ability to join different materials.
Xu, Botao
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source