Results 101 to 110 of about 253,748 (293)

Enhancing patient care quality and safety under the hospital-wide “One Bed” model: a FMEA-based approach

Frontiers in Medicine
BackgroundThe hospital-wide “One Bed” model poses potential risks in cross-departmental patient care, affecting nursing quality and patient safety. However, systematic evaluation and improvement strategies for these risks remain limited.ObjectiveThis ...
Xixi Li, Yanfei Ma, Haili Long, Jianying Shang, Zhi Zeng, Haiyan Wang, Li Wan, Huaping Huang   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Quality by Design for industry translation: Three‐dimensional risk assessment failure mode, effects, and criticality analysis for additively manufactured patient‐specific implants

, 2020
The complexity of patient‐specific implants combined with the current limited expertise in reliability engineering and manufacturability in the additive manufacturing (AM) sector is posing a number of quality performance challenges.
Peter Scheinemann, Martinez‐Marquez, Daniel, Terhaer, Klemens, Christopher P. Carty, Carty, Christopher P, Daniel Martinez‐Marquez, Mirnajafizadeh, Ali, Stewart, Rodney A, Ali Mirnajafizadeh, Rodney A. Stewart, Scheinemann, Peter, Klemens Terhaer   +11 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Failure mode and effects analysis of software-based automation systems

, 2002
Failure mode and effects analysis (FMEA) is one of the well-known analysis methods having an established position in the traditional reliability analysis.
Helminen, Atte, Haapanen, Pentti
core   +1 more source

Using functional analysis diagrams to improve product reliability and cost

Advances in Mechanical Engineering, 2016
Failure mode and effects analysis and value engineering are well-established methods in the manufacturing industry, commonly applied to optimize product reliability and cost, respectively.
Ioannis Michalakoudis, Peter Childs, Marco Aurisicchio, James Harding   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Identifying Critical Failures in PV Systems Based on PV Inverters’ Monitoring Unit: A Techno-Economic Analysis

Energies
Recent advancements in power electronics have significantly improved photovoltaic (PV) inverters by equipping them with sophisticated monitoring capabilities.
Filipe Monteiro, Eduardo Sarquis, Paulo Branco   +2 more
doaj   +1 more source