Results 101 to 110 of about 1,193,680 (335)

Independent Orbiter Assessment (IOA): Analysis of the atmospheric revitalization pressure control subsystem [PDF]

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis/Critical Items List (FMEA/CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality, and ...
Duffy, R. E., Mclaughlin, T. D., Saiidi, M. J.   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Clinical Risk Assessment of Intensive Care Unit using Failure Mode and Effects Analysis

بیمارستان, 2015
Background: The goal of clinical risk management is to improve the quality of health care organization’s services and to ensure patientschr('39') safety.
Farnaz Attar Jannesar Nobari, Taraneh Yousefinezhadi, Faranak Behzadi Goodari, Mohammad Arab   +3 more
doaj  

A novel decision-making approach for risk assessment of converter steelmaking process based on fuzzy DEMATEL method

Alexandria Engineering Journal
Converter steelmaking is a critical process in steel production, facing various failure modes with severe safety and operational risks. However, comprehensive risk assessments in this area remain limited.
Fei Gao, Ding Zhou
doaj   +1 more source

Geometrically nonlinear analysis of adhesively bonded joints [PDF]

A geometrically nonlinear finite element analysis of cohesive failure in typical joints is presented. Cracked-lap-shear joints were chosen for analysis.
Dattaguru, B., Everett, R. A., Jr., Johnson, W. S., Whitcomb, J. D.   +3 more
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Risk Factor Assessment in a Carpet Manufacturing Company Using the Failure Modes and Effects Analysis in Mazandaran

تحقیقات سلامت در جامعه, 2019
Introduction and purpose: The most prevalent accidents and injuries occur in industries. Risk assessment and risk management are the basis for planning to provide solutions and control hazards.
solale ramzani, mirtaghi mirmohammadi
doaj  

Production Improvement through Fixture Design: A Case Study of an Agricultural Machinery Parts Manufacturer

RMUTL Engineering Journal
This case study focuses on a manufacturing company producing agricultural machinery parts. The company faced a significant challenge: it could not meet customer demand due to inefficiencies in the production process.
Bhoomboon Phontang, Jetnipat Pimollukanakul, Thamrong Gearam, Jittiwat Nithikarnjanatharn, Supattra Muparang, Wannisa Nutkhum   +5 more
doaj   +1 more source

Risk Assessment of a Tunnelling Process Using Machinery Failure Mode and Effects Analysis (MFMEA) [PDF]

In recent years, risk management associated with safety and reliability of the process especially in oil and gas industry has been widely used. For this purpose, different methods of risk analysis have been developed and successfully applied.
جعفری, محمدجواد, قراری, نورالدین   +1 more
core