Results 121 to 130 of about 253,748 (293)

Methodology of using an integrated averaging technique and MAUT method for failure mode and effects analysis [PDF]

, 2016
The conventional Failure Mode and Effects Analysis (FMEA) which is popularly used for prioritizing risk of failure modes of industrial products has limitations such as the inability of the technique to utilize imprecise ratings from experts.
Farah Nadhirah
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Failure Mode and Effects Analysis for Experimental Use of FLASH on a Clinical Accelerator. [PDF]

Pract Radiat Oncol, 2023
Rahman M, Zhang R, Gladstone DJ, Williams BB, Chen E, Dexter CA, Thompson L, Bruza P, Pogue BW.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Failure Mode and Effect Analysis in Increasing the Revenue of Emergency Department

طب اورژانس ایران, 2015
Introduction: Successful performance of emergency department(ED) is one of the important indications of increasing the satisfaction among referees.
Farhad Rahmati, Ali Shahrami, Alireza Baratloo, Behrooz Hashemi, Nastaran Sadat Mahdavi, Saeed Safari, Hamidreza Hatamabadi   +6 more
doaj  

Numerical modelling of composite laminates with through-thickness-reinforcements [PDF]

, 2004
The main objective of the present research study was to develop numerical models to investigate the mechanical properties and effectiveness of z-fibre reinforced laminates.
Grassi, Marcello
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Development application of FMEA risk assessment model for indoor air pollutants in healthcare organizations: Focus on suspended particles and bioaerosols in hospitals

MethodsX
This study aimed to develop the Failure Mode and Effects Analysis (FMEA) and Decision Matrix Risk Assessment (DMRA) technique for the first time to assess risks associated with particulate matter (PM) and bioaerosol transmission in hospitals.
Mahbubeh Tangestani, Ahmad Jonidi Jafari, Majid Kermani, Roshanak Rezaei Kalantary   +3 more
doaj   +1 more source