Results 131 to 140 of about 253,748 (293)

Procedure for Failure Mode, Effects, and Criticality Analysis (FMECA)

open access: yes, 1966
This document provides guidelines for the accomplishment of Failure Mode, Effects, and Criticality Analysis (FMECA) on the Apollo program. It is a procedure for analysis of hardware items to determine those items contributing most to system unreliability

core  

Risk-based Reliability Assessment of Subsea Control module for Offshore Oil and Gas production [PDF]

open access: yes, 2014
Offshore oil and gas exploitation is principally conducted using dry or wet tree systems, otherwise called the subsea Xmas tree system. Due to the shift to deeper waters, subsea production system (SPS) has come to be a preferred technology with ...
Umofia, Anietie Nnana
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Safety Management in an Oil Company through Failure Mode Effects and Critical Analysis

open access: yesJurnal Teknik Industri, 2016
This study attempts to apply Failure Mode Effects and Criticality Analysis (FMECA) to improve the safety of a production system, specifically the production process of an oil company.
Benedictus Rahardjo
doaj  

Application of failure mode and effects analysis to validate a novel hybrid Linac QC program that integrates automated and conventional QC testing. [PDF]

open access: yesJ Appl Clin Med Phys, 2022
Pearson M   +6 more
europepmc   +1 more source

Lunar Mass Spectrometer reliability failure mode effects and criticality analysis and single point failure

open access: yes, 1972
Presented herein are the Failure Mode Effects and Criticality Analysis and the Single Point Failure Summary for the Lunar Mass Spectrometer. The "A" Revision was required to include the Lock Out Switching Circuit(see page 174 for description).
Hiebert, Robert W.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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