Results 51 to 60 of about 1,169,414 (346)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Application of failure mode and effects analysis in ecology in Russia

MATEC Web of Conferences, 2018
The article presents a comprehensive review of the FMEA analysis (the failure modes and effects analysis) in the construction industry in the Russian Federation and suggests the same analysis, which can be applied to ecological issues. The paper analyzes
Borkovskaya Victoria, Passmore David
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Reliability failure mode, effects, and criticality analysis : addendum 1; HFE [PDF]

, 1971
This addendum is an update to 501 B for Heat Flow Experiment (HFE), Array A-2, D, E. Contained in this addendum is the discussion of the changes and the updated Failure Mode, Effects and Criticality Analysis (FMECA) Work Sheets.prepared by R.W. Hiebert.B-
Hiebert, Robert W.
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Risk Assessment for Failure Mode and Effects Analysis Using the Bonferroni Mean and TODIM Method

Mathematics, 2019
As a safety and reliability analysis technique, failure mode and effects analysis (FMEA) has been used extensively in several industries for the identification and elimination of known and potential failures.
Jianghong Zhu, Bin Shuai, Rui Wang, Kwai-Sang Chin   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Procedure for Failure Mode, Effects, and Criticality Analysis (FMECA) [PDF]

This document provides guidelines for the accomplishment of Failure Mode, Effects, and Criticality Analysis (FMECA) on the Apollo program. It is a procedure for analysis of hardware items to determine those items contributing most to system unreliability

core   +1 more source

Finite Element Analysis of FRP Debonding Failure at the Tip of Flexural/Shear Crack in Concrete Beam [PDF]

, 2013
One of the most common failure modes of strengthened RC beams with externally bonded FRP is intermediate crack (IC) debonding of FRP initiated at the tip of flexural/shear cracks. This study presents a method, using extended finite element method (XFEM),
Harries, Kent, Mohammadi, Tayyebeh, Wan, Baolin   +2 more
core   +1 more source