Results 71 to 80 of about 1,169,414 (346)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Maintenance Analysis of Raw Mill Machines in Cement Production

Engineering Proceedings
PT X is one of the companies that produces cement in Indonesia. Engine breakdowns do happen occasionally in raw mill machines in PT X. This study analyzed the cause of occasional breakdowns.
Aditya Chandra Nugroho, Taurista Perdana Syawitri, Rafi Miftachul An’am   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Failure mode and effects analysis and sensitivity analysis for a neutral point re-injection multi-pulse voltage source converter

e-Prime: Advances in Electrical Engineering, Electronics and Energy
Sensitivity Analysis plays a crucial role in the design, control, and optimization of multi-pulse Voltage Source Converters. It helps engineers assess how variations in parameters influence system performance, enabling the development of more efficient ...
A. Valderrabano-Gonzalez, H.R. Robles-Campos, F. Beltran-Carbajal, R. Tapia-Olvera, J.C. Rosas-Caro, O. Aguilar-Mejia   +5 more
doaj   +1 more source

An analysis for providing safety in the cooking oil production process through FMECA approach [PDF]

, 2016
This study attempts to apply Failure Mode Effects and Criticality Analysis (FMECA) to improve the safety of production system, espe-cially on the production process of an oil company in Indonesia.
Jiang, Bernard C., Rahardjo, Benedictus
core   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Independent Orbiter Assessment (IOA): Analysis of the life support and airlock support subsystems [PDF]

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality ...
Arbet, Jim, Barickman, K., Duffy, R., Saiidi, Mo J.   +3 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Reliability of a Tunnel Boring Machine [PDF]

Greater levels of complexity in tunnelling with Tunnel Boring Machine (TBM) allow higher chances of fail-ures that may increase the potential hazardous risks. This paper presents the results of a study on TBM reliability using risk analysis.
جعفری, محمدجواد, قراری, نورالدین   +1 more
core  

Concrete beams with externally bonded flexural FRP-reinforcement: analytical investigation of debonding failure [PDF]

, 2003
This paper studies the problem of early concrete cover delamination and plate-end failure of reinforced concrete beams strengthened with externally bonded FRP-reinforcement. The accuracy of analytical models and finite element (FE) methods for predicting
Adams, Arduini, Fanning, Garden, Goland, Kwak, Kypros Pilakoutas, Lau, Malek, Meier, Nguyen, Ninoslav Pešić, Quantrill, Rahimi, Ramana, Ritchie, Robert, Roberts, Roberts, Ross, Saadatmanesh, Saadatmanesh, Sharif, Smith, Spadea, Taljsten, Teng, Triantafillou, Volkersen   +28 more
core   +1 more source