Results 41 to 50 of about 4,967,084 (293)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
EnergiesRecently, the demand for electricity in Iraq has increased; therefore, there is an increased demand for generating and transmitting electrical power. Furthermore, Iraq’s electricity grid is interconnected with neighboring countries to supply electricity ...
Athraa Ali Kadhem
doaj +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Optimization Method of Pipeline Inspection Period Considering Corrosion Defects
Shiyou jixie, 2020 Internal inspection is an important means to identify risks and ensure the safe operation of oil and gas pipelines. A cost-based optimization method with a failure probability threshold as a decisive variable is proposed to balance risk and cost, and ...
Zhang Jie +6 more
doaj
Energies, 2020 This paper presents a review of the existing models for the estimation of explosion-induced crushed and cracked zones. The control of these zones is of utmost importance in the rock explosion design, since it aims at optimizing the fragmentation and, as ...
Mahdi Shadabfar +4 more
doaj +1 more source
Frontiers in Materials, 2023 A solid oxide fuel cell (SOFC) is an all-solid-state chemical power generation device that converts chemical energy into electrical energy in an efficient and environmentally friendly way in medium- and high-temperature environments. However, the thermal
Yun Luo +5 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frontiers in Earth Science, 2022 Shallow hillslope failure caused by rainfall is characterized by complex soil hydrology and mechanical behavior. It is important to understand the hydraulic behavior of hillslopes and quantify the effect of the uncertainty of mechanical parameters on ...
Ya-Sin Yang +4 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source