Results 61 to 70 of about 4,219,187 (348)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Detection Performance in Balanced Binary Relay Trees with Node and Link Failures

open access: yes, 2012
We study the distributed detection problem in the context of a balanced binary relay tree, where the leaves of the tree correspond to $N$ identical and independent sensors generating binary messages.
Chong, Edwin K. P.   +4 more
core   +2 more sources

Patients' self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death. [PDF]

open access: yes, 2010
BACKGROUND: Clinician-assigned New York Heart Association (NYHA) class is an established predictor of outcomes in heart failure. This study aims to test whether patients' self-assessment of functional status by NYHA class predicts hospital admissions ...
Brooksby, Iain   +4 more
core   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Creep rupture of materials: insights from a fiber bundle model with relaxation

open access: yes, 2010
I adapted a model recently introduced in the context of seismic phenomena, to study creep rupture of materials. It consists of linear elastic fibers that interact in an equal load sharing scheme, complemented with a local viscoelastic relaxation ...
E. A. Jagla, H. Kawamura, K. Yamaguchi
core   +1 more source

Failure Rate Estimation in a Dynamic Environment [PDF]

open access: yesEconomic Quality Control, 2015
Abstract We present a method to assess the reliability of a material operating in a dynamic environment. The dynamic environment is represented as a sequence of shocks governed by a self-exciting point process. The time-to-failure of the material is assumed to have a piecewise exponential distribution.
Gouno, Evans, Guérineau, Lise
openaire   +4 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

A 12-month clinical study comparing four Glass Ionomer Cements for the cementation of orthodontic molar bands

open access: yesAustralasian Orthodontic Journal, 1989
Four different glass ionomer cements were evaluated in vivo as luting agents for orthodontic mohu bands. A sample of 199 patients with full fixed appliances (Begg Light Wire) were monitored over a period of 12 months during active treatment for loose ...
Fricker John P.
doaj   +1 more source

Model of correlation between geometry of thermoelectric branches and reliability indicators of single-stage coolers in Q0max mode

open access: yesTekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2016
The authors consider the influence of the geometry of thermoelectric branches on the performance reliability of single-stage thermoelectric devices (TED) operating at maximum cooling capacity at 2.0 W thermal load for any values of temperature difference
B. P. Зайков   +2 more
doaj   +1 more source

Parameter Estimates of General Failure Rate Model: A Bayesian Approach [PDF]

open access: yes, 2014
The failure rate function plays an important role in studying the lifetime distributions in reliability theory and life testing models. A study of the general failure rate model $r(t)=a+bt^{\theta-1}$, under squared error loss function taking $a$ and $b$
Kundu, Amarjit   +3 more
core  

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