Results 31 to 40 of about 2,001,528 (211)

Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape

BMC Bioinformatics, 2010
Background Failure on Highly Active Anti-Retroviral Treatment is often accompanied with development of antiviral resistance to one or more drugs included in the treatment.
Camacho Ricardo J, Lemey Philippe, van Laethem Kristel, Moreau Yves, Beheydt Gertjan, Deforche Koen, Theys Kristof, Rhee Soo-Yon, Shafer Robert W, Van Wijngaerden Eric, Vandamme Anne-Mieke   +10 more
doaj   +1 more source

Chemotherapy confers a conserved secondary tolerance to EGFR inhibition via AXL-mediated signaling bypass

Scientific Reports, 2021
Drug resistance remains the major culprit of therapy failure in disseminated cancers. Simultaneous resistance to multiple, chemically different drugs feeds this failure resulting in cancer relapse.
Mark Borris D. Aldonza, Roben D. Delos Reyes, Young Seo Kim, Jayoung Ku, Ana Melisa Barsallo, Ji-Young Hong, Sang Kook Lee, Han Suk Ryu, YongKeun Park, Je-Yoel Cho, Yoosik Kim   +10 more
doaj   +1 more source

Addressing the Challenges of Hepatitis C Virus Resistance and Treatment Failure

Viruses, 2016
Chronic hepatitis C is a major cause of chronic liver disease, including liver cirrhosis and hepatocellular carcinoma. The development of direct-acting antivirals (DAAs) revolutionized hepatitis C virus (HCV) treatment by offering genuine prospects for ...
Che C. Colpitts, Thomas F. Baumert
doaj   +1 more source

Simulation-Based Analysis of the Heating Behavior of Failed Bypass Diodes in Photovoltaic-Module Strings

Energies
With the expansion of photovoltaic (PV) systems, failures of bypass diodes (BPDs) embedded in PV modules can degrade the power-generation performance and pose safety risks.
Ibuki Kitamura, Ikuo Nanno, Norio Ishikura, Masayuki Fujii, Shinichiro Oke, Toshiyuki Hamada   +5 more
doaj   +1 more source

Ultrafiltration in Diuretic-Resistant Cardiac Failure

Renal Failure, 1987
Ultrafiltration was performed in 13 patients with diuretic-resistant cardiac failure. All patients had severely distressing peripheral edema and ultrafiltration was successfully completed in 12 patients, all of whom sustained symptomatic improvement. The volume of fluid removed ranged from 3.7 to 23 L, mean 11.8 L.
I A, Simpson, K, Simpson, A P, Rae, J M, Boulton-Jones, M E, Allison, I, Hutton   +5 more
openaire   +2 more sources

Cyclic fatigue resistance, torsional resistance, and metallurgical characteristics of M3 Rotary and M3 Pro Gold NiTi files [PDF]

, 2018
Objectives: To evaluate the mechanical properties and metallurgical characteristics of the M3 Rotary and M3 Pro Gold files (United Dental). Materials and Methods: One hundred and sixty new M3 Rotary and M3 Pro Gold files (sizes 20/0.04 and 25/0.04) were
Bruno, Elena, Chang, Seok Woo, Gambarini, Gianluca, La Rosa, Giusy Rita Maria, La Rosa, Guido, Lo Savio, Fabio, Miccoli, Gabriele, Pedullà, Eugenio, Rapisarda, Ernesto, Rapisarda, Silvia, Testarelli, Luca   +10 more
core   +1 more source

Resistant and Refractory Hypertension: Antihypertensive Treatment Resistance vs Treatment Failure [PDF]

Canadian Journal of Cardiology, 2016
Resistant or difficult to treat hypertension is defined as high blood pressure that remains uncontrolled with 3 or more different antihypertensive medications, including a diuretic. Recent definitions also include controlled blood pressure with use of 4 or more medications as also being resistant to treatment.
Mohammed, Siddiqui, Tanja, Dudenbostel, David A, Calhoun   +2 more
openaire   +2 more sources

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

, 2014
Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy.
A. Lorz, A. Lorz, A. Wu, A.L. Correia, A.O. Pisco, A.S. Silva, B. Baguley, C. Bock, D. Woods, D.W. McMillin, E.S. Nakasone, F.A. Meineke, G. Lambert, H. Zahreddine, H.M. Byrne, I. Bozic, J. Foo, J. Foo, J. Greene, J.J. Cunningham, J.J. Kim, J.J. Lee, K. Cheung-Ong, M. Dean, M. Sawicka, M.M. Hadjiandreou, N.L. Komarova, N.L. Komarova, O. Lavi, O. Lavi, O. Trédan, P. Karran, P.A. Orlando, P.P. Provenzano, S. Rottenberg, S.M. Mumenthaler, T. Brocato, T.L. Jackson   +37 more
core   +1 more source

Prevalence, risk factors, and treatment outcomes of isoniazid- and rifampicin-mono-resistant pulmonary tuberculosis in Lima, Peru [PDF]

, 2016
Background : Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the association of mono-resistance ...
Gotuzzo, Eduardo, Huaman, Moises A, Otero Vegas, Larissa, Seas, Carlos, Sterling, Timothy R, Van Der Stuyft, Patrick, Villegas, Leonela   +6 more
core   +9 more sources

Resistance training improves hemodynamic function, collagen deposition and inflammatory profiles: experimental model of heart failure. [PDF]

PLoS ONE, 2014
The role of resistance training on collagen deposition, the inflammatory profile and muscle weakness in heart failure remains unclear. Therefore, this study evaluated the influence of a resistance training program on hemodynamic function, maximum ...
Jadson P Alves, Ramiro B Nunes, Giuseppe P Stefani, Pedro Dal Lago   +3 more
doaj   +1 more source