Results 111 to 120 of about 2,294,345 (331)
, 2022 This slide deck contains presentation of following topics: 1. Overview of FAIR data principles 2. Controlled vocabularies 3. DCAT schema 4. Share Wind Semantic Data Portal (Kristina Tomicic)
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Decentralised Semantics: A Semantic Engine User Perspective
Data Science JournalThe Findable, Accessible, Interoperable and Reusable (FAIR) data principles were created to guide the improvement of research data (Wilkinson et al., 2016). As data curators and educators, we often see individual research groups and researchers establish
Carly M. Huitema +3 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
, 2023 This is a short presentation about the FAIR Data Fund, managed by the 4TU.ResearchData that was presented during the OPEN and FAIR Networking event for the OSCD and 4TU.ResearchData communities on 14 September 2023.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
State of the Data: Assessing the FAIRness of US Geological Survey Data
Data Science JournalIn response to recent shifts towards open science that emphasize transparency, reproducibility, and access to research data, the US Geological Survey (USGS) conducted a study to assess the degree to which USGS data assets meet the FAIR data principles ...
Vivian B. Hutchison +3 more
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