Results 241 to 250 of about 444,200 (304)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Enabling FAIR data stewardship in complex international multi-site studies: Data Operations for the Accelerating Medicines Partnership® Schizophrenia Program. [PDF]

Schizophrenia (Heidelb)
Billah T, Cho KIK, Borders O, Chung Y, Ennis M, Jacobs GR, Liebenthal E, Mathalon DH, Mohandass D, Nicholas SC, Pasternak O, Penzel N, Eichi HR, Wolff P, Anticevic A, Laulette K, Nunez AR, Tamayo Z, Buccilli K, Colton BL, Dwyer DB, Hendricks L, Yuen HP, Spark J, Tod S, Carrington H, Chen JT, Coleman MJ, Corcoran CM, Haidar A, John O, Kelly S, Marcy PJ, Matneja P, McGowan A, Ray SE, Veale S, Winter-Van Rossum I, Addington J, Allott KA, Calkins ME, Clark SR, Gur RC, Harms MP, Perkins DO, Ruparel K, Stone WS, Torous J, Yung AR, Zoupou E, Fusar-Poli P, Mittal VA, Shah JL, Wolf DH, Cecchi G, Kapur T, Kubicki M, Lewandowski KE, Bearden CE, McGorry PD, Kahn RS, Kane JM, Nelson B, Woods SW, Shenton ME, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Baker JT, Bouix S.   +67 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

FAIR data retrieval for sensitive clinical research data in Galaxy. [PDF]

Gigascience
Ouwerkerk J, Rasche H, Spalding JD, Hiltemann S, Stubbs AP.   +4 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A Framework for the Interoperability of Cloud Platforms: Towards FAIR Data in SAFE Environments. [PDF]

Sci Data
Grossman RL, Boyles RR, Davis-Dusenbery BN, Haddock A, Heath AP, O'Connor BD, Resnick AC, Taylor DM, Ahalt S.   +8 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists. [PDF]

Sci Data
Seep L, Grein S, Splichalova I, Ran D, Mikhael M, Hildebrand S, Lauterbach M, Hiller K, Ribeiro DJS, Sieckmann K, Kardinal R, Huang H, Yu J, Kallabis S, Behrens J, Till A, Peeva V, Strohmeyer A, Bruder J, Blum T, Soriano-Arroquia A, Tischer D, Kuellmer K, Li Y, Beyer M, Gellner AK, Fromme T, Wackerhage H, Klingenspor M, Fenske WK, Scheja L, Meissner F, Schlitzer A, Mass E, Wachten D, Latz E, Pfeifer A, Hasenauer J.   +37 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source